2-((4R,5R)-4,5-Diphenyl-4,5-dihydro-oxazol-2-yl)-benzoic acid methyl ester

Base Information

Chemical Name:2-((4R,5R)-4,5-Diphenyl-4,5-dihydro-oxazol-2-yl)-benzoic acid methyl ester
CAS No.:404926-55-2
Molecular Formula:C₂₃H₁₉NO₃
Molecular Weight:357.409
Hs Code.:

Synonyms:2-((4R,5R)-4,5-Diphenyl-4,5-dihydro-oxazol-2-yl)-benzoic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-((4R,5R)-4,5-Diphenyl-4,5-dihydro-oxazol-2-yl)-benzoic acid methyl ester

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Technology Process of 2-((4R,5R)-4,5-Diphenyl-4,5-dihydro-oxazol-2-yl)-benzoic acid methyl ester

There total 3 articles about 2-((4R,5R)-4,5-Diphenyl-4,5-dihydro-oxazol-2-yl)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 404926-54-1
N-((1R,2S)-2-Hydroxy-1,2-diphenyl-ethyl)-phthalamic acid methyl ester

: 404926-55-2
2-((4R,5R)-4,5-Diphenyl-4,5-dihydro-oxazol-2-yl)-benzoic acid methyl ester

Guidance literature:: With thionyl chloride; at 20 ℃; for 2h;
DOI:10.1055/s-2001-18754

Reference yield:

: 4376-18-5
Monomethyl phthalate

: 404926-55-2
2-((4R,5R)-4,5-Diphenyl-4,5-dihydro-oxazol-2-yl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / (COCl)2; DMF / CH₂Cl₂ / 4 h / 0 - 20 °C

2: 61 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

3: 59 percent / SOCl₂ / 2 h / 20 °C

With thionyl chloride; oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1055/s-2001-18754

Reference yield:

: 4397-55-1
phthalic monoacid monomethyl ester chloride

: 404926-55-2
2-((4R,5R)-4,5-Diphenyl-4,5-dihydro-oxazol-2-yl)-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

2: 59 percent / SOCl₂ / 2 h / 20 °C

With thionyl chloride; triethylamine; In dichloromethane;
DOI:10.1055/s-2001-18754