Technology Process of C19H18F2O2
There total 5 articles about C19H18F2O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl-triphenylphosphonium iodide;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 0.0833333h;
Inert atmosphere;
C18H16F2O3;
In
tetrahydrofuran;
at -78 - 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1002/anie.201105138
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sulfuric acid / 16 h / Reflux; Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.08 h / 0 - 20 °C / Inert atmosphere
2.2: 4 h / -78 - 20 °C / Inert atmosphere
With
sulfuric acid; lithium hexamethyldisilazane;
In
tetrahydrofuran;
1.1: Fischer esterification / 2.1: Whiting reaction / 2.2: Whiting reaction;
DOI:10.1002/anie.201105138
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran / -105 - -70 °C / Inert atmosphere
1.2: 1.25 h / -105 - -50 °C / Inert atmosphere
2.1: sulfuric acid / 16 h / Reflux; Inert atmosphere
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.08 h / 0 - 20 °C / Inert atmosphere
3.2: 4 h / -78 - 20 °C / Inert atmosphere
With
n-butyllithium; sulfuric acid; lithium hexamethyldisilazane;
In
tetrahydrofuran;
2.1: Fischer esterification / 3.1: Whiting reaction / 3.2: Whiting reaction;
DOI:10.1002/anie.201105138
