(4R,4 aR,8aS)-methyl-4-(4-fluorophenyl)-8 a-hydroxy-4 a-nitro-4a,5,6,7,8,8 a-hexahydro-4H-chromene-2-carboxylate

Base Information

Chemical Name:(4R,4 aR,8aS)-methyl-4-(4-fluorophenyl)-8 a-hydroxy-4 a-nitro-4a,5,6,7,8,8 a-hexahydro-4H-chromene-2-carboxylate
CAS No.:1403680-42-1
Molecular Formula:C₁₇H₁₈FNO₆
Molecular Weight:351.331
Hs Code.:

Synonyms:(4R,4 aR,8aS)-methyl-4-(4-fluorophenyl)-8 a-hydroxy-4 a-nitro-4a,5,6,7,8,8 a-hexahydro-4H-chromene-2-carboxylate

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Chemical Property of (4R,4 aR,8aS)-methyl-4-(4-fluorophenyl)-8 a-hydroxy-4 a-nitro-4a,5,6,7,8,8 a-hexahydro-4H-chromene-2-carboxylate

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Technology Process of (4R,4 aR,8aS)-methyl-4-(4-fluorophenyl)-8 a-hydroxy-4 a-nitro-4a,5,6,7,8,8 a-hexahydro-4H-chromene-2-carboxylate

There total 1 articles about (4R,4 aR,8aS)-methyl-4-(4-fluorophenyl)-8 a-hydroxy-4 a-nitro-4a,5,6,7,8,8 a-hexahydro-4H-chromene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 960382-66-5
C₁₁H₉FO₃

: 4883-67-4
2-nitrocyclohexanone

: methyl-4-(4-fluorophenyl)-8 a-hydroxy-4 a-nitro-4a,5,6,7,8,8 a-hexahydro-4H-chromene-2-carboxylate

: 1403680-42-1
(4R,4 aR,8aS)-methyl-4-(4-fluorophenyl)-8 a-hydroxy-4 a-nitro-4a,5,6,7,8,8 a-hexahydro-4H-chromene-2-carboxylate

Guidance literature:: C₁₁H₉FO₃; With 1-(((1R,4aS,10aR)-7-isopropyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthren-1-yl)methyl)-3-((1S,2S)-2-(pyrrolidin-1-yl)cyclohexyl)thiourea; In tert-butyl methyl ether; 1,2-dichloro-ethane; at -13 ℃; for 0.5h; Inert atmosphere;

2-nitrocyclohexanone; In tert-butyl methyl ether; 1,2-dichloro-ethane; for 36h; Overall yield = 83 %; stereoselective reaction; Inert atmosphere;
DOI:10.1002/chem.201201102 DOI:10.1002/chem.201201102

Reference yield: 61.0%

: 1403680-42-1
(4R,4 aR,8aS)-methyl-4-(4-fluorophenyl)-8 a-hydroxy-4 a-nitro-4a,5,6,7,8,8 a-hexahydro-4H-chromene-2-carboxylate

: 1403680-55-6
(7S,8R,Z)-methyl 8-(4-fluorophenyl)-7-nitro-2-oxo-3,4,5,6,7,8-hexahydro-2H-oxecine-10-carboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 4h; enantioselective reaction; Inert atmosphere; Reflux;
DOI:10.1002/chem.201201102 DOI:10.1002/chem.201201102