Technology Process of (R)-4a-Ethyl-2,3,4,4a,5,6-hexahydro-7-<(4-methoxyphenyl)sulfonyl>-7H-pyrido<3,2-c>carbazole
There total 13 articles about (R)-4a-Ethyl-2,3,4,4a,5,6-hexahydro-7-<(4-methoxyphenyl)sulfonyl>-7H-pyrido<3,2-c>carbazole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol; acetic acid;
at 20 ℃;
for 24h;
under 3800 Torr;
DOI:10.1021/jo00088a008
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 74 percent / 1 N aq. HCl / tetrahydrofuran / 3 h
2: 94 percent / p-TsOH / toluene / 5 h / Heating
3: 84 percent / NaH, CuI / hexamethylphosphoric acid triamide / 2.) 120 deg C, 2 h
4: 1.) 1 N lithium triethylborohydride; 6 N aq. NaOH, 2.) 30percent H2O2 / 1.) THF, 1 h; EtOH, 2.) room temp., 15 h
5: Et3N, 4-(dimethylamino)pyridine / CH2Cl2; tetrahydrofuran / 2 h / 0 °C
6: sodium azide / dimethylformamide / 2 h / 80 °C
7: tetrabutylammonium hydrogenosulfate, 50percent aq. NaOH / CH2Cl2 / 2 h
8: 91 percent / H2 / 10percent Pd-C / ethanol; acetic acid / 24 h / 20 °C / 3800 Torr
With
hydrogenchloride; dmap; sodium hydroxide; copper(l) iodide; sodium azide; hydrogen; dihydrogen peroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydride; lithium triethylborohydride; toluene-4-sulfonic acid; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00088a008
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Et3N, 4-(dimethylamino)pyridine / CH2Cl2; tetrahydrofuran / 2 h / 0 °C
2: sodium azide / dimethylformamide / 2 h / 80 °C
3: tetrabutylammonium hydrogenosulfate, 50percent aq. NaOH / CH2Cl2 / 2 h
4: 91 percent / H2 / 10percent Pd-C / ethanol; acetic acid / 24 h / 20 °C / 3800 Torr
With
dmap; sodium hydroxide; sodium azide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jo00088a008
