1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4S)-4-{3-[2-(2-hydroxy-ethylsulfanyl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy}-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea

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Chemical Name:1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4S)-4-{3-[2-(2-hydroxy-ethylsulfanyl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy}-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea
CAS No.:1351997-11-9
Molecular Formula:C₃₉H₄₁N₇O₃S
Molecular Weight:687.866
Hs Code.:

1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4S)-4-{3-[2-(2-hydroxy-ethylsulfanyl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy}-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea

Synonyms:1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4S)-4-{3-[2-(2-hydroxy-ethylsulfanyl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy}-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea

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Chemical Property of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4S)-4-{3-[2-(2-hydroxy-ethylsulfanyl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy}-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea

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Technology Process of 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4S)-4-{3-[2-(2-hydroxy-ethylsulfanyl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy}-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea

There total 11 articles about 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4S)-4-{3-[2-(2-hydroxy-ethylsulfanyl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy}-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1351997-29-9
1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[(1S,4S)-4-(3-{2-[2-(tetrahydropyran-2-yloxy)ethyIsuIfanyI]phenyl}-[1,2,4]triazoIo[4,3-a]pyridin-6-yIoxy)-1,2,3,4-tetrahydronaphthalen-1-yl]urea

: 1351997-11-9
1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4S)-4-{3-[2-(2-hydroxy-ethylsulfanyl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy}-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 - 60 ℃; for 8h;

Reference yield: 44.0%

: 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[(1S,4S)-4-(3-{2-[2-(tetrahydro-pyran-2-yloxy)-ethylsulfanyl]-phenyl}-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy)-1,2,3,4-tetrahydro-naphthalen-1-yl]-urea

: 1351997-11-9
1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4S)-4-{3-[2-(2-hydroxy-ethylsulfanyl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy}-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 20 - 60 ℃; for 8h;

Reference yield:

: 529-34-0
3,4-dihydronaphthalene-1(2H)-one

: 1351997-11-9
1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-((1S,4S)-4-{3-[2-(2-hydroxy-ethylsulfanyl)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy}-1,2,3,4-tetrahydro-naphthalen-1-yl)-urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / tetrachloromethane / 1.25 h / Reflux; Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

1.3: 0 - 20 °C / Inert atmosphere

2.1: potassium tert-butylate; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / 3.5 h / 50 - 80 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 h / 80 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol / 8 h / 20 - 60 °C

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium tert-butylate; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; tetrachloromethane;