2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenyl}butanoylamino)-2-methylpropanoic acid

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Chemical Name:2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenyl}butanoylamino)-2-methylpropanoic acid
CAS No.:662110-51-2
Molecular Formula:C₃₆H₄₉N₃O₁₃
Molecular Weight:731.797
Hs Code.:

Synonyms:2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenyl}butanoylamino)-2-methylpropanoic acid

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Chemical Property of 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenyl}butanoylamino)-2-methylpropanoic acid

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Technology Process of 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenyl}butanoylamino)-2-methylpropanoic acid

There total 6 articles about 2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenyl}butanoylamino)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₃H₅₅N₃O₁₃

: 662110-51-2
2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenyl}butanoylamino)-2-methylpropanoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; water; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2012.11.041

Reference yield:

: 1422008-74-9
benzyl 4-(4-formyl-3-methylphenyl)butanoate

: 662110-51-2
2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenyl}butanoylamino)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: sodium tetrahydroborate / tetrahydrofuran / 4 h / 20 °C

2: triethylamine / tetrahydrofuran / 0.33 h / 0 °C

3: sodium hydride / tetrahydrofuran / 10 h / 0 °C / Reflux

4: hydrazine hydrate / isopropyl alcohol / 20 °C

5: benzyltri(n-butyl)ammonium chloride; sodium hydroxide / dichloromethane / 20 °C

6: palladium 10% on activated carbon; hydrogen / methanol; water / 20 °C

7: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

8: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / 20 °C

With sodium tetrahydroborate; palladium 10% on activated carbon; hydrogen; benzyltri(n-butyl)ammonium chloride; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmc.2012.11.041

Reference yield:

: C₂₀H₂₄O₅S

: 662110-51-2
2-(4-{4-[3-(tetra-O-acetyl-β-d-glucopyranosyloxy)-5-isopropyl-1H-pyrazol-4-ylmethyl]-3-methylphenyl}butanoylamino)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / tetrahydrofuran / 10 h / 0 °C / Reflux

2: hydrazine hydrate / isopropyl alcohol / 20 °C

3: benzyltri(n-butyl)ammonium chloride; sodium hydroxide / dichloromethane / 20 °C

4: palladium 10% on activated carbon; hydrogen / methanol; water / 20 °C

5: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

6: palladium 10% on activated carbon; hydrogen / methanol; water / 2 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzyltri(n-butyl)ammonium chloride; sodium hydride; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmc.2012.11.041