2,6-bis[(1R,2S)-N,N'-2-chloro-1,2-diphenylethyl]pyridinedicarboxamide

Base Information

• Chemical Name: 2,6-bis[(1R,2S)-N,N'-2-chloro-1,2-diphenylethyl]pyridinedicarboxamide
• CAS No.: 410092-97-6
• Molecular Formula: C₃₅H₂₉Cl₂N₃O₂
• Molecular Weight: 594.54
• Mol file: 410092-97-6.mol

Synonyms:2,6-bis[(1R,2S)-N,N'-2-chloro-1,2-diphenylethyl]pyridinedicarboxamide

Chemical Property of 2,6-bis[(1R,2S)-N,N'-2-chloro-1,2-diphenylethyl]pyridinedicarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-bis[(1R,2S)-N,N'-2-chloro-1,2-diphenylethyl]pyridinedicarboxamide

There total 3 articles about 2,6-bis[(1R,2S)-N,N'-2-chloro-1,2-diphenylethyl]pyridinedicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,6-bis[(1R,2S)-N,N'-2-hydroxy-1,2-diphenylethyl]pyridinedicarboxamide (410092-96-5) → 2,6-bis[(1R,2S)-N,N'-2-chloro-1,2-diphenylethyl]pyridinedicarboxamide (410092-97-6)

Guidance literature:

With thionyl chloride; In dichloromethane; for 3h; Heating;

DOI:10.1016/S0040-4020(01)01055-9

Reference yield:

(1S,2R)-2-Amino-1,2-diphenylethanol (23364-44-5) → 2,6-bis[(1R,2S)-N,N'-2-chloro-1,2-diphenylethyl]pyridinedicarboxamide (410092-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / Et₃N / CH₂Cl₂ / 15 h / -5 °C

2: 97 percent / SOCl₂ / CH₂Cl₂ / 3 h / Heating

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(01)01055-9

Reference yield:

2,6-Pyridinedicarbonyl dichloride (3739-94-4) → 2,6-bis[(1R,2S)-N,N'-2-chloro-1,2-diphenylethyl]pyridinedicarboxamide (410092-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / Et₃N / CH₂Cl₂ / 15 h / -5 °C

2: 97 percent / SOCl₂ / CH₂Cl₂ / 3 h / Heating

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1016/S0040-4020(01)01055-9

upstream raw materials:

2,6-bis[(1R,2S)-N,N'-2-hydroxy-1,2-diphenylethyl]pyridinedicarboxamide

(1S,2R)-2-Amino-1,2-diphenylethanol

2,6-Pyridinedicarbonyl dichloride

Downstream raw materials:

2,6-bis[(4R,5R)-4,5-diphenyl-4,5-dihydro-1,3-oxazol-2-yl]pyridine