3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzoic acid

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Chemical Name:3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzoic acid
CAS No.:1310530-75-6
Molecular Formula:C₂₄H₂₂N₈O₂
Molecular Weight:454.491
Hs Code.:

Synonyms:3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzoic acid

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Chemical Property of 3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzoic acid

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Technology Process of 3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzoic acid

There total 7 articles about 3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1310530-05-2
3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzonitrile

: 1310530-75-6
3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzoic acid

Guidance literature:: 3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzonitrile; With potassium hydroxide; In ethanol; water; at 20 - 80 ℃;

With hydrogenchloride; In water; pH=6;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1310530-75-6
3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrahydrofuran / 16 h / 60 °C

2.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 - 100 °C

3.1: zinc; ammonium formate / ethanol / 2 h / 50 °C

4.1: Oxone / N,N-dimethyl-formamide; water / 3 h / 20 °C

5.1: potassium hydroxide / ethanol; water / 20 - 80 °C

5.2: pH 6

With Oxone; ammonium formate; potassium carbonate; potassium hydroxide; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1135351-95-9
4-bromo-N-(tert-butyl)-2-nitroaniline

: 1310530-75-6
3-[5-(2-aminopyrimidin-5-yl)-1-tert-butyl-1H-benzimidazol-2-yl]-4-1,2,4-triazol-1-ylbenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 20 - 100 °C

2.1: zinc; ammonium formate / ethanol / 2 h / 50 °C

3.1: Oxone / N,N-dimethyl-formamide; water / 3 h / 20 °C

4.1: potassium hydroxide / ethanol; water / 20 - 80 °C

4.2: pH 6

With Oxone; ammonium formate; potassium carbonate; potassium hydroxide; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; N,N-dimethyl-formamide;