(R)-4-amino-5-(4-phenoxyphenyl)-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid

Base Information

Chemical Name:(R)-4-amino-5-(4-phenoxyphenyl)-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid
CAS No.:1610698-36-6
Molecular Formula:C₂₃H₂₁N₅O₃
Molecular Weight:415.451
Hs Code.:

Synonyms:(R)-4-amino-5-(4-phenoxyphenyl)-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid

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Chemical Property of (R)-4-amino-5-(4-phenoxyphenyl)-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid

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Technology Process of (R)-4-amino-5-(4-phenoxyphenyl)-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid

There total 6 articles about (R)-4-amino-5-(4-phenoxyphenyl)-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₉N₅O₅

: 1610698-36-6
(R)-4-amino-5-(4-phenoxyphenyl)-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: With hydrogenchloride; Inert atmosphere; Cooling with ice;

Reference yield:

: 1610697-81-8
tert-butyl (R)-3-(4-amino-6-bromo-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylate

: 1610698-36-6
(R)-4-amino-5-(4-phenoxyphenyl)-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 100 °C / Inert atmosphere

2: sodium hydroxide; water / ethylene glycol / 150 °C / Inert atmosphere

3: hydrogenchloride / Inert atmosphere; Cooling with ice

With hydrogenchloride; water; sodium hydroxide; In ethylene glycol; N,N-dimethyl-formamide;

Reference yield:

: 1272668-51-5
(R)-3-(4-chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidin-7-yl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1610698-36-6
(R)-4-amino-5-(4-phenoxyphenyl)-7-(pyrrolidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium hydroxide / 1,4-dioxane / 0.83 h / 120 °C / Microwave irradiation; Sealed tube

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / 1,2-dimethoxyethane; water / 90 °C / Inert atmosphere

3: N-Bromosuccinimide / dichloromethane / 0.5 h / 20 °C

4: N,N-dimethyl-formamide / 100 °C / Inert atmosphere

5: sodium hydroxide; water / ethylene glycol / 150 °C / Inert atmosphere

6: hydrogenchloride / Inert atmosphere; Cooling with ice

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; ammonium hydroxide; N-Bromosuccinimide; water; sodium carbonate; sodium hydroxide; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; ethylene glycol; N,N-dimethyl-formamide;