(S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)pyrrolidin-2-one

Base Information

Chemical Name:(S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)pyrrolidin-2-one
CAS No.:1433881-01-6
Molecular Formula:C₂₂H₃₀FN₅O₃S₂
Molecular Weight:495.642
Hs Code.:

Synonyms:(S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)pyrrolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)pyrrolidin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)pyrrolidin-2-one

There total 10 articles about (S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.1%

: 1351168-04-1
(S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one

: 1433886-81-7
N-(methylsulfonyloxy)isobutyrimidoyl chloride

: 540-72-7
sodium thiocyanide

: 1433881-01-6
(S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)pyrrolidin-2-one

Guidance literature:: N-(methylsulfonyloxy)isobutyrimidoyl chloride; sodium thiocyanide; With pyridine; In acetonitrile; at 45 ℃; for 0.75h;

(S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(piperidin-4-yl)pyrrolidin-2-one; In acetonitrile; at 45 ℃;

Reference yield:

: 1351167-89-9
(S)-benzyl 4-(3-(tert-butoxycarbonylamino)-2-oxopyrrolidin-1-yl)piperidin-1-carboxylate

: 1433881-01-6
(S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 95 °C / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / ethanol

4.1: pyridine / acetonitrile / 0.75 h / 45 °C

4.2: 45 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In ethanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1351167-90-2
(S)-benzyl 4-(3-amino-2-oxopyrrolidin-1-yl)piperidin-1-carboxylate

: 1433881-01-6
(S)-3-(2-fluoro-5-methyl-4-(methylsulfonyl)phenylamino)-1-(1-(3-isopropyl-1,2,4-thiadiazol-5-yl)piperidin-4-yl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 95 °C / Inert atmosphere

2.1: hydrogen; palladium 10% on activated carbon / ethanol

3.1: pyridine / acetonitrile / 0.75 h / 45 °C

3.2: 45 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; toluene; acetonitrile;