Technology Process of 7α-propoxy-17α-(4'-iodophenylethynyl)estra-1,3,5(10)-triene-3,17βdiol
There total 10 articles about 7α-propoxy-17α-(4'-iodophenylethynyl)estra-1,3,5(10)-triene-3,17βdiol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine;
In
tetrahydrofuran;
for 3h;
Reflux;
Inert atmosphere;
DOI:10.1016/j.steroids.2012.05.004
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 2,2-Dimethyl-1,3-propanediol; toluene-4-sulfonic acid / benzene / 4 h / Reflux
2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 0 - 20 °C / pH 8
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
4.1: sodium hydride / tetrahydrofuran / 20 h / Reflux
5.1: 10% Pd/C; hydrogen / tetrahydrofuran / 24 h / 20 °C / 760.05 Torr
6.1: sodium carbonate; toluene-4-sulfonic acid / water; acetone / 15 h / 20 °C
7.1: 1H-imidazole / N,N-dimethyl-formamide / 10 h / 0 - 20 °C
8.1: lithium diisopropyl amide / tetrahydrofuran; ethylbenzene; n-heptane / 1 h / -78 - 0 °C
8.2: 15 h / -78 °C
9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / -10 - 20 °C
10.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / tetrahydrofuran / 3 h / Reflux; Inert atmosphere
With
1H-imidazole; copper(l) iodide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium(0); 10% Pd/C; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; triethylamine; 2,2-Dimethyl-1,3-propanediol; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; water; N,N-dimethyl-formamide; acetone; benzene;
DOI:10.1016/j.steroids.2012.05.004
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 0 - 20 °C / pH 8
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran / 20 h / Reflux
4.1: 10% Pd/C; hydrogen / tetrahydrofuran / 24 h / 20 °C / 760.05 Torr
5.1: sodium carbonate; toluene-4-sulfonic acid / water; acetone / 15 h / 20 °C
6.1: 1H-imidazole / N,N-dimethyl-formamide / 10 h / 0 - 20 °C
7.1: lithium diisopropyl amide / tetrahydrofuran; ethylbenzene; n-heptane / 1 h / -78 - 0 °C
7.2: 15 h / -78 °C
8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / -10 - 20 °C
9.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / tetrahydrofuran / 3 h / Reflux; Inert atmosphere
With
1H-imidazole; copper(l) iodide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium(0); 10% Pd/C; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; sodium carbonate; toluene-4-sulfonic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide;
In
tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.steroids.2012.05.004
