tert-butyl 4-[[benzyl-(2-hydroxy-2-phenyl-ethyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[[benzyl-(2-hydroxy-2-phenyl-ethyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate
CAS No.:1400642-59-2
Molecular Formula:C₂₆H₃₆N₂O₄
Molecular Weight:440.583
Hs Code.:

Synonyms:tert-butyl 4-[[benzyl-(2-hydroxy-2-phenyl-ethyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[[benzyl-(2-hydroxy-2-phenyl-ethyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-[[benzyl-(2-hydroxy-2-phenyl-ethyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate

There total 1 articles about tert-butyl 4-[[benzyl-(2-hydroxy-2-phenyl-ethyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51096-49-2,91579-12-3,107171-75-5,27159-30-4
2-benzylamino-1-phenyl-ethanol

: 147804-30-6
1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester

: 1400642-59-2
tert-butyl 4-[[benzyl-(2-hydroxy-2-phenyl-ethyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate

Guidance literature:: In ethanol; at 75 ℃;

Reference yield:

: 1400642-59-2
tert-butyl 4-[[benzyl-(2-hydroxy-2-phenyl-ethyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate

: 1400642-60-5
4-benzyl-2-phenyl-1-oxa-4,9-diazaspiro[5.5]undecane

Guidance literature:: tert-butyl 4-[[benzyl-(2-hydroxy-2-phenyl-ethyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate; With hydrogen bromide; In water; at 55 ℃; for 10h;

With sodium hydroxide; In water; pH=13;

Reference yield:

: 1400642-59-2
tert-butyl 4-[[benzyl-(2-hydroxy-2-phenyl-ethyl)amino]methyl]-4-hydroxy-piperidine-1-carboxylate

: 1400642-62-7
tert-butyl 8-phenyl-7-oxa-3,10-diazaspiro[5.5]undecane-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen bromide / water / 10 h / 55 °C

1.2: pH 13

2.1: dichloromethane / 2 h

3.1: ammonium formate / palladium(II) hydroxide / ethanol / 0.67 h / 60 °C

With hydrogen bromide; ammonium formate; palladium(II) hydroxide; In ethanol; dichloromethane; water;