5'-O-(3'-deoxy-2',3'-didehydrothymidinyl)-O-(4-methylphenyl)-N-[(S)-benzylalaninyl]-phosphoramidate

Base Information

Chemical Name:5'-O-(3'-deoxy-2',3'-didehydrothymidinyl)-O-(4-methylphenyl)-N-[(S)-benzylalaninyl]-phosphoramidate
CAS No.:1334335-90-8
Molecular Formula:C₂₇H₃₀N₃O₈P
Molecular Weight:555.524
Hs Code.:

Synonyms:5'-O-(3'-deoxy-2',3'-didehydrothymidinyl)-O-(4-methylphenyl)-N-[(S)-benzylalaninyl]-phosphoramidate

Suppliers and Price of 5'-O-(3'-deoxy-2',3'-didehydrothymidinyl)-O-(4-methylphenyl)-N-[(S)-benzylalaninyl]-phosphoramidate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5'-O-(3'-deoxy-2',3'-didehydrothymidinyl)-O-(4-methylphenyl)-N-[(S)-benzylalaninyl]-phosphoramidate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5'-O-(3'-deoxy-2',3'-didehydrothymidinyl)-O-(4-methylphenyl)-N-[(S)-benzylalaninyl]-phosphoramidate

There total 2 articles about 5'-O-(3'-deoxy-2',3'-didehydrothymidinyl)-O-(4-methylphenyl)-N-[(S)-benzylalaninyl]-phosphoramidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1334335-86-2
4-methylphenyl-N-[(S)-benzylalaninyl]-[(S)-4-isopropylthiazolidine-2-thione]phosphorodiamidate

: 3056-17-5
stavudin

: 1334335-90-8
5'-O-(3'-deoxy-2',3'-didehydrothymidinyl)-O-(4-methylphenyl)-N-[(S)-benzylalaninyl]-phosphoramidate

Guidance literature:: stavudin; With tert-butylmagnesium chloride; In tetrahydrofuran; acetonitrile; at 0 - 20 ℃; Inert atmosphere;

4-methylphenyl-N-[(S)-benzylalaninyl]-[(S)-4-isopropylthiazolidine-2-thione]phosphorodiamidate; In tetrahydrofuran; acetonitrile; at 0 - 20 ℃; optical yield given as %de; diastereospecific reaction; Inert atmosphere;
DOI:10.1002/ejoc.201100614

Reference yield:

: 1254939-85-9
4-methylphenyl [(S)-4-isopropylthiazolidine-2-thione]phosphorochloridate

: 1334335-90-8
5'-O-(3'-deoxy-2',3'-didehydrothymidinyl)-O-(4-methylphenyl)-N-[(S)-benzylalaninyl]-phosphoramidate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

2.1: tert-butylmagnesium chloride / tetrahydrofuran; acetonitrile / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With tert-butylmagnesium chloride; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/ejoc.201100614