3-(3-(mercaptomethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine

Base Information

• Chemical Name: 3-(3-(mercaptomethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine
• CAS No.: 321851-06-3
• Molecular Formula: C₉H₇F₃N₂S
• Molecular Weight: 232.229
• Mol file: 321851-06-3.mol

Synonyms:3-(3-(mercaptomethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine

Chemical Property of 3-(3-(mercaptomethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-(3-(mercaptomethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine

There total 3 articles about 3-(3-(mercaptomethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-(3-((acetylthio)methyl)phenyl)-3-trifluoromethyl-3H-diazirine → 3-(3-(mercaptomethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine (321851-06-3)

Guidance literature:

With sodium methylate; In methanol; at 20 ℃; for 0.166667h;

DOI:10.1002/chem.200304925

Reference yield:

3-(3-methylphenyl)-3-trifluoromethyl-3H-diazirine (870562-44-0) → 3-(3-(mercaptomethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine (321851-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / NBS; AIBN / CCl₄ / 1 h / Heating

2: 76 percent / acetonitrile / 1 h / 20 °C

3: 83 percent / sodium methoxide / methanol / 0.17 h / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium methylate; In methanol; tetrachloromethane; acetonitrile;

DOI:10.1002/chem.200304925

Reference yield:

3-[3'-(bromomethyl)phenyl]-3-(trifluoromethyl)-3H-diazirine (162845-02-5) → 3-(3-(mercaptomethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine (321851-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / acetonitrile / 1 h / 20 °C

2: 83 percent / sodium methoxide / methanol / 0.17 h / 20 °C

With sodium methylate; In methanol; acetonitrile;

DOI:10.1002/chem.200304925

upstream raw materials:

3-(3-methylphenyl)-3-trifluoromethyl-3H-diazirine

3-[3'-(bromomethyl)phenyl]-3-(trifluoromethyl)-3H-diazirine

Downstream raw materials:

C₁₅H₁₇F₃N₂O₅S₂