(4S)-4-Chloro-<3-oxo-3-<2-oxo-4-(phenylmethyl)-3-oxazolidinyl>propyl>benzene

Base Information

Chemical Name:(4S)-4-Chloro-<3-oxo-3-<2-oxo-4-(phenylmethyl)-3-oxazolidinyl>propyl>benzene
CAS No.:159750-01-3
Molecular Formula:C₁₉H₁₈ClNO₃
Molecular Weight:343.81
Hs Code.:

Synonyms:(4S)-4-Chloro-<3-oxo-3-<2-oxo-4-(phenylmethyl)-3-oxazolidinyl>propyl>benzene

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Chemical Property of (4S)-4-Chloro-<3-oxo-3-<2-oxo-4-(phenylmethyl)-3-oxazolidinyl>propyl>benzene

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Technology Process of (4S)-4-Chloro-<3-oxo-3-<2-oxo-4-(phenylmethyl)-3-oxazolidinyl>propyl>benzene

There total 4 articles about (4S)-4-Chloro-<3-oxo-3-<2-oxo-4-(phenylmethyl)-3-oxazolidinyl>propyl>benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2019-34-3
3-(4-chlorophenyl)propanoic acid

: 90719-32-7
(S)-4-Benzyl-2-oxazolidinone

: 159750-01-3
(4S)-4-Chloro-<3-oxo-3-<2-oxo-4-(phenylmethyl)-3-oxazolidinyl>propyl>benzene

Guidance literature:: 3-(4-chlorophenyl)propanoic acid; With pivaloyl chloride; triethylamine; In tetrahydrofuran; at -10 ℃; for 1h; Inert atmosphere;

(S)-4-Benzyl-2-oxazolidinone; With lithium chloride; In tetrahydrofuran; at -10 - 20 ℃; Inert atmosphere;

Reference yield:

: 1615-02-7,940-62-5
3-(4-chlorophenyl)prop-2-enoic acid

: 159750-01-3
(4S)-4-Chloro-<3-oxo-3-<2-oxo-4-(phenylmethyl)-3-oxazolidinyl>propyl>benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / H₂ / 10percent Pd-C / tetrahydrofuran / 4 h / Ambient temperature

2: Et₃N / tetrahydrofuran / 1.) -78 deg C, 15 min, 2.) 0 deg C, 45 min

3: n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) -78 deg C, 15 min and room temp., 10 h

With n-butyllithium; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jo00088a009

Reference yield:

: 2019-34-3
3-(4-chlorophenyl)propanoic acid

: 159750-01-3
(4S)-4-Chloro-<3-oxo-3-<2-oxo-4-(phenylmethyl)-3-oxazolidinyl>propyl>benzene

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 1.) -78 deg C, 15 min, 2.) 0 deg C, 45 min

2: n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) -78 deg C, 15 min and room temp., 10 h

With n-butyllithium; triethylamine; In tetrahydrofuran;
DOI:10.1021/jo00088a009