(1S,2R,4S,5R)-3-Oxa-6-azatricyclo[3.2.1.02,4]octan-7-one

Base Information

Chemical Name:(1S,2R,4S,5R)-3-Oxa-6-azatricyclo[3.2.1.02,4]octan-7-one
CAS No.:329910-40-9
Molecular Formula:C6H7 N O2
Molecular Weight:0
Hs Code.:
Nikkaji Number:J1.148.996F
Mol file:329910-40-9.mol

Synonyms:127801-86-9;(1S,2R,4S,5R)-3-OXA-6-AZATRICYCLO[3.2.1.02,4]OCTAN-7-ONE;3-Oxa-6-azatricyclo[3.2.1.02,4]octan-7-one,(1R,2S,4R,5S)-rel-(9CI);SCHEMBL18582006

Suppliers and Price of (1S,2R,4S,5R)-3-Oxa-6-azatricyclo[3.2.1.02,4]octan-7-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (1S,2R,4S,5R)-3-Oxa-6-azatricyclo[3.2.1.02,4]octan-7-one

Chemical Property:

PSA：45.12000
LogP:-0.45200
XLogP3:-0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:125.047678466
Heavy Atom Count:9
Complexity:192

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2C3C(C1NC2=O)O3
Isomeric SMILES:C1[C@H]2[C@@H]3[C@H]([C@@H]1NC2=O)O3

Technology Process of (1S,2R,4S,5R)-3-Oxa-6-azatricyclo[3.2.1.02,4]octan-7-one

There total 2 articles about (1S,2R,4S,5R)-3-Oxa-6-azatricyclo[3.2.1.02,4]octan-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.16%

: 79200-56-9
(-)-2-azabicyclo[2.2.1]hept-5-en-3-one

: 329910-40-9,244075-39-6
(1S,2R,4S,5R)-3-oxa-6-azatricyclo[3.2.1.02,4]octan-7-one

Guidance literature:: With disodium hydrogenphosphate; sodium dihydrogenphosphate; In water; at 0 ℃; for 7h; pH=6;

Reference yield:

: 79200-56-9
(-)-2-azabicyclo[2.2.1]hept-5-en-3-one

: 244075-39-6
(1S,2S,4R,5R)-3-Oxa-6-aza-tricyclo[3.2.1.0^2,4]octan-7-one

: 329910-40-9,244075-39-6
(1S,2R,4S,5R)-3-oxa-6-azatricyclo[3.2.1.02,4]octan-7-one

Guidance literature:: With Oxone; In water; for 7h; pH=6;
DOI:10.1016/S0040-4039(00)02210-3

Reference yield:

: 329910-40-9,244075-39-6
(1S,2R,4S,5R)-3-oxa-6-azatricyclo[3.2.1.02,4]octan-7-one

: 321744-16-5,321744-18-7
(1R,2R,4S)-1-(tert-butoxycarbonylamino)-2-hydroxycyclopentane-4-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / DMAP / CH₂Cl₂ / 5 h / 0 - 20 °C

2: 100 percent / NaOMe / methanol / 16 h / 0 - 20 °C

3: H₂ / [(COD)py(PCy₃)]PF₆ / methanol / 14 h

With dmap; hydrogen; sodium methylate; [(COD)py(PCy₃)]PF₆; In methanol; dichloromethane;
DOI:10.1016/S0040-4039(00)02210-3