Ethyl (E)-4-(2-{2-[2-(3,4-dimethoxyphenyl)ethylcarbamoyl]-1-methylvinyl}benzofuran-7-yloxy)butyrate

Base Information

• Chemical Name: Ethyl (E)-4-(2-{2-[2-(3,4-dimethoxyphenyl)ethylcarbamoyl]-1-methylvinyl}benzofuran-7-yloxy)butyrate
• CAS No.: 803684-65-3
• Molecular Formula: C₂₈H₃₃NO₇
• Molecular Weight: 495.573

Synonyms:Ethyl (E)-4-(2-{2-[2-(3,4-dimethoxyphenyl)ethylcarbamoyl]-1-methylvinyl}benzofuran-7-yloxy)butyrate

Chemical Property of Ethyl (E)-4-(2-{2-[2-(3,4-dimethoxyphenyl)ethylcarbamoyl]-1-methylvinyl}benzofuran-7-yloxy)butyrate

Chemical Property:

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Technology Process of Ethyl (E)-4-(2-{2-[2-(3,4-dimethoxyphenyl)ethylcarbamoyl]-1-methylvinyl}benzofuran-7-yloxy)butyrate

There total 5 articles about Ethyl (E)-4-(2-{2-[2-(3,4-dimethoxyphenyl)ethylcarbamoyl]-1-methylvinyl}benzofuran-7-yloxy)butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.8%

diethyl [2-(2-(3,4-dimethoxyphenyl)ethylamino)-2-oxoethyl]phosphonate (826992-39-6) + ethyl 4-(2-acetylbenzofuran-7-yloxy)butyrate (803686-20-6) → 4-(2-{(Z)-2-[2-(3,4-Dimethoxy-phenyl)-ethylcarbamoyl]-1-methyl-vinyl}-benzofuran-7-yloxy)-butyric acid ethyl ester + Ethyl (E)-4-(2-{2-[2-(3,4-dimethoxyphenyl)ethylcarbamoyl]-1-methylvinyl}benzofuran-7-yloxy)butyrate (803684-65-3)

Guidance literature:

diethyl [2-(2-(3,4-dimethoxyphenyl)ethylamino)-2-oxoethyl]phosphonate; With sodium hydride; In tetrahydrofuran; at 25 ℃;

ethyl 4-(2-acetylbenzofuran-7-yloxy)butyrate; In tetrahydrofuran; at 25 ℃; for 4h;

DOI:10.1039/b503615a

Reference yield:

2-acetyl-7-hydroxybenzofuran (40020-87-9) → Ethyl (E)-4-(2-{2-[2-(3,4-dimethoxyphenyl)ethylcarbamoyl]-1-methylvinyl}benzofuran-7-yloxy)butyrate (803684-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 72.2 percent / K₂CO₃ / acetone / 2 h / 54 °C

2.1: NaH / tetrahydrofuran / 25 °C

2.2: 39.8 percent / tetrahydrofuran / 4 h / 25 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; acetone; 2.2: Horner-Wadsworth-Emmons reaction;

DOI:10.1039/b503615a

Reference yield:

2-chloro-N-(2-(3,4-dimethoxyphenyl)ethyl)acetamide (14301-31-6) → Ethyl (E)-4-(2-{2-[2-(3,4-dimethoxyphenyl)ethylcarbamoyl]-1-methylvinyl}benzofuran-7-yloxy)butyrate (803684-65-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 0.7 g / 15 h / 130 °C

2.1: NaH / tetrahydrofuran / 25 °C

2.2: 39.8 percent / tetrahydrofuran / 4 h / 25 °C

With sodium hydride; In tetrahydrofuran; 2.2: Horner-Wadsworth-Emmons reaction;

DOI:10.1039/b503615a

upstream raw materials:

diethyl [2-(2-(3,4-dimethoxyphenyl)ethylamino)-2-oxoethyl]phosphonate

ethyl 4-(2-acetylbenzofuran-7-yloxy)butyrate

2-acetyl-7-hydroxybenzofuran

2-chloro-N-(2-(3,4-dimethoxyphenyl)ethyl)acetamide

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