O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl phosphorofluoridate

Base Information

Chemical Name:O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl phosphorofluoridate
CAS No.:171081-34-8
Molecular Formula:C₃₅H₄₀FN₂O₉P
Molecular Weight:682.683
Hs Code.:

Synonyms:O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl phosphorofluoridate

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Chemical Property of O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl phosphorofluoridate

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Technology Process of O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl phosphorofluoridate

There total 3 articles about O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl phosphorofluoridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 171081-30-4
O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl phosphorofluoridite

: 171081-34-8
O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl phosphorofluoridate

Guidance literature:: With tert.-butylhydroperoxide; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1039/b103082p

Reference yield:

: C₃₇H₄₅FN₃O₇P

: 171081-34-8
O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl phosphorofluoridate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrazole / acetonitrile / 0.17 h / Ambient temperature

2: tert-butyl hydroperoxide

With 1H-tetrazole; tert.-butylhydroperoxide; In acetonitrile;
DOI:10.1246/cl.1995.727

Reference yield:

: 76054-81-4
3'-O-(4,4'-dimethoxytrityl)thymidine

: 171081-34-8
O-[3'-O-(4,4'-dimethoxytrityl)thymidin-5'-yl] O-tert-butyl phosphorofluoridate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / TMSCl / tetrahydrofuran / 1 h / 20 °C

2: 98 percent / tert-butyl hydroperoxide / tetrahydrofuran / 1 h / 20 °C

With tert.-butylhydroperoxide; chloro-trimethyl-silane; In tetrahydrofuran;
DOI:10.1039/b103082p