2-[[1-[(2R)-2-methyl-3-(phenylmethoxy)-1-propyl]diphenylsilyl]-2-phenylethyl]-1H-isoindole-1,3(2H)-dione

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Chemical Name:2-[[1-[(2R)-2-methyl-3-(phenylmethoxy)-1-propyl]diphenylsilyl]-2-phenylethyl]-1H-isoindole-1,3(2H)-dione
CAS No.:727726-44-5
Molecular Formula:C₃₉H₃₇NO₃Si
Molecular Weight:595.813
Hs Code.:

Synonyms:2-[[1-[(2R)-2-methyl-3-(phenylmethoxy)-1-propyl]diphenylsilyl]-2-phenylethyl]-1H-isoindole-1,3(2H)-dione

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Chemical Property of 2-[[1-[(2R)-2-methyl-3-(phenylmethoxy)-1-propyl]diphenylsilyl]-2-phenylethyl]-1H-isoindole-1,3(2H)-dione

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Technology Process of 2-[[1-[(2R)-2-methyl-3-(phenylmethoxy)-1-propyl]diphenylsilyl]-2-phenylethyl]-1H-isoindole-1,3(2H)-dione

There total 10 articles about 2-[[1-[(2R)-2-methyl-3-(phenylmethoxy)-1-propyl]diphenylsilyl]-2-phenylethyl]-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 136918-14-4,85-41-6
phthalimide

: 727726-42-3
[(2R)-2-methyl-3-(phenylmethoxy)-1-propyl][2-phenyl-1-hydroxyethyl]diphenylsilane

: 727726-44-5
2-[[1-[(2R)-2-methyl-3-(phenylmethoxy)-1-propyl]diphenylsilyl]-2-phenylethyl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1021/jo048121v

Reference yield:

: 63930-46-1
(S)-3-benzyloxy-2-methylpropan-1-ol

: 727726-44-5
2-[[1-[(2R)-2-methyl-3-(phenylmethoxy)-1-propyl]diphenylsilyl]-2-phenylethyl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent / iodine; triphenylphosphine; imidazole / diethyl ether; acetonitrile / 3.5 h / 0 °C

2.1: tert-butyllithium / pentane; diethyl ether / 0.83 h / -78 - 20 °C

2.2: 65 percent / diethyl ether; pentane / -78 - 20 °C

3.1: 73 percent / HgCl₂; water / acetonitrile / 1.25 h / 20 °C

4.1: 100 percent / LiAlH₄ / diethyl ether / 3 h / 0 - 20 °C

5.1: 63 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; water; iodine; tert.-butyl lithium; triphenylphosphine; mercury dichloride; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; acetonitrile; pentane;
DOI:10.1021/jo048121v

Reference yield:

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 727726-44-5
2-[[1-[(2R)-2-methyl-3-(phenylmethoxy)-1-propyl]diphenylsilyl]-2-phenylethyl]-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: TfOH

2.1: lithium aluminum hydride

3.1: 85 percent / iodine; triphenylphosphine; imidazole / diethyl ether; acetonitrile / 3.5 h / 0 °C

4.1: tert-butyllithium / pentane; diethyl ether / 0.83 h / -78 - 20 °C

4.2: 65 percent / diethyl ether; pentane / -78 - 20 °C

5.1: 73 percent / HgCl₂; water / acetonitrile / 1.25 h / 20 °C

6.1: 100 percent / LiAlH₄ / diethyl ether / 3 h / 0 - 20 °C

7.1: 63 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 24 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; trifluorormethanesulfonic acid; water; iodine; tert.-butyl lithium; triphenylphosphine; mercury dichloride; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; acetonitrile; pentane;
DOI:10.1021/jo048121v