p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Base Information

Chemical Name:p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate
CAS No.:105675-88-5
Molecular Formula:C₂₃H₂₇N₃O₇S
Molecular Weight:489.549
Hs Code.:

p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2-<cis-4-carbamoylcyclohexylthio>-(5R)-carbapen-2-em-3-carboxylate

Synonyms:p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

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Chemical Property of p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

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Technology Process of p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

There total 4 articles about p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74346-66-0
3,3-bis-(1,2,4-triazol-1-yl)-2-thiabicyclo<2.2.2.>oct-5-ene

: 105675-88-5
p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 86.8 percent / hydrogen / 10percent Pd/C / ethyl acetate / 20 h / 2585.7 Torr / Ambient temperature

2: 89.8 percent / 1N HCl / Heating

3: 90.1 percent / conc. NH₄OH / 20 h / Ambient temperature

4: 1) diphenylchlorophosphate, (i-Pr)2NH / 1) CH₃CN, 0 to 5 deg C, 1 h, 2) DMF, RT, 3 d

With hydrogenchloride; ammonium hydroxide; hydrogen; diisopropylamine; chlorophosphoric acid diphenyl ester; palladium on activated charcoal; In ethyl acetate;

Reference yield:

: 105676-16-2
2-thiabicyclo<2.2.2>octane-3-one

: 105675-88-5
p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 90.1 percent / conc. NH₄OH / 20 h / Ambient temperature

2: 1) diphenylchlorophosphate, (i-Pr)2NH / 1) CH₃CN, 0 to 5 deg C, 1 h, 2) DMF, RT, 3 d

With ammonium hydroxide; diisopropylamine; chlorophosphoric acid diphenyl ester;

Reference yield:

: 105737-63-1
3,3-bis(1,2,4-triazol-1-yl)-2-thiabicyclo<2.2.2>octane

: 105675-88-5
p-nitrobenzyl (6S)-<(1R)-hydroxyethyl>-2--(5R)-carbapen-2-em-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 89.8 percent / 1N HCl / Heating

2: 90.1 percent / conc. NH₄OH / 20 h / Ambient temperature

3: 1) diphenylchlorophosphate, (i-Pr)2NH / 1) CH₃CN, 0 to 5 deg C, 1 h, 2) DMF, RT, 3 d

With hydrogenchloride; ammonium hydroxide; diisopropylamine; chlorophosphoric acid diphenyl ester;