1-(4-Hydroxyphenyl)-5-[4-(methylsulfonyl)phenyl]-3-(difluoromethyl)pyrazole

Base Information

Chemical Name:1-(4-Hydroxyphenyl)-5-[4-(methylsulfonyl)phenyl]-3-(difluoromethyl)pyrazole
CAS No.:151507-20-9
Molecular Formula:C₁₇H₁₄F₂N₂O₃S
Molecular Weight:364.373
Hs Code.:

Synonyms:1-(4-Hydroxyphenyl)-5-[4-(methylsulfonyl)phenyl]-3-(difluoromethyl)pyrazole

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Chemical Property of 1-(4-Hydroxyphenyl)-5-[4-(methylsulfonyl)phenyl]-3-(difluoromethyl)pyrazole

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Technology Process of 1-(4-Hydroxyphenyl)-5-[4-(methylsulfonyl)phenyl]-3-(difluoromethyl)pyrazole

There total 5 articles about 1-(4-Hydroxyphenyl)-5-[4-(methylsulfonyl)phenyl]-3-(difluoromethyl)pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 151506-45-5
3-(difluoromethyl)-1-(4-methoxyphenyl)-5-[4-(methylsulfonyl)phenyl]pyrazole

: 151507-20-9
1-(4-Hydroxyphenyl)-5-[4-(methylsulfonyl)phenyl]-3-(difluoromethyl)pyrazole

Guidance literature:: With boron tribromide; In dichloromethane; at 5 ℃; for 2h;
DOI:10.1248/cpb.45.1475

Reference yield:

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 151507-20-9
1-(4-Hydroxyphenyl)-5-[4-(methylsulfonyl)phenyl]-3-(difluoromethyl)pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: AcOH / 1 h / Heating

2: 39 percent / 30percent aq. H₂O₂, H₂SO₄, AcOH / 1 h / 60 °C

3: 97 percent / BBr₃ / CH₂Cl₂ / 2 h / 5 °C

With sulfuric acid; dihydrogen peroxide; boron tribromide; acetic acid; In dichloromethane;
DOI:10.1248/cpb.45.1475

Reference yield:

: 134731-37-6
4,4-difluoro-1-[4-(methylthio)phenyl]-butane-1,3-dione

: 151507-20-9
1-(4-Hydroxyphenyl)-5-[4-(methylsulfonyl)phenyl]-3-(difluoromethyl)pyrazole

Guidance literature:: Multi-step reaction with 3 steps

1: AcOH / 1 h / Heating

2: 39 percent / 30percent aq. H₂O₂, H₂SO₄, AcOH / 1 h / 60 °C

3: 97 percent / BBr₃ / CH₂Cl₂ / 2 h / 5 °C

With sulfuric acid; dihydrogen peroxide; boron tribromide; acetic acid; In dichloromethane;
DOI:10.1248/cpb.45.1475