2H-Cyclohepta[b]furan-2-one, octahydro-5,7-dihydroxy-4,6-dimethyl-, (3aR,4S,5S,6R,7S,8aS)-rel- (9CI)

Base Information

Chemical Name:2H-Cyclohepta[b]furan-2-one, octahydro-5,7-dihydroxy-4,6-dimethyl-, (3aR,4S,5S,6R,7S,8aS)-rel- (9CI)
CAS No.:328394-37-2
Molecular Formula:C₁₁H₁₈O₄
Molecular Weight:214.262
Hs Code.:
Mol file:328394-37-2.mol

Synonyms:2H-Cyclohepta[b]furan-2-one, octahydro-5,7-dihydroxy-4,6-dimethyl-, (3aR,4S,5S,6R,7S,8aS)-rel- (9CI)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2H-Cyclohepta[b]furan-2-one, octahydro-5,7-dihydroxy-4,6-dimethyl-, (3aR,4S,5S,6R,7S,8aS)-rel- (9CI)

Chemical Property:

PSA：66.76000
LogP:0.31580

Purity/Quality:

Safty Information:

Pictogram(s):
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Technology Process of 2H-Cyclohepta[b]furan-2-one, octahydro-5,7-dihydroxy-4,6-dimethyl-, (3aR,4S,5S,6R,7S,8aS)-rel- (9CI)

There total 3 articles about 2H-Cyclohepta[b]furan-2-one, octahydro-5,7-dihydroxy-4,6-dimethyl-, (3aR,4S,5S,6R,7S,8aS)-rel- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 401911-96-4
((1R,4R,5S,7R)-4-Hydroxy-5,7-dimethyl-6-oxo-cyclohept-2-enyl)-acetic acid methyl ester

: 328394-37-2
(3aS,4R,5R,6S,7R,8aR)-5,7-Dihydroxy-4,6-dimethyl-octahydro-cyclohepta[b]furan-2-one

Guidance literature:: Multistep reaction.;
DOI:10.1021/ol0003836

Reference yield:

: 401911-77-1
tert-Butyl-((1S,4S,5R)-2,4-dimethyl-8-oxa-bicyclo[3.2.1]octa-2,6-dien-3-yloxy)-dimethyl-silane

: 328394-37-2
(3aS,4R,5R,6S,7R,8aR)-5,7-Dihydroxy-4,6-dimethyl-octahydro-cyclohepta[b]furan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: LiClO₄ / diethyl ether / 0 °C

2: 98 percent / TBAF / acetic acid; tetrahydrofuran / 60 h

3: 80 percent

With tetrabutyl ammonium fluoride; lithium perchlorate; In tetrahydrofuran; diethyl ether; acetic acid;
DOI:10.1021/ol0003836

Reference yield:

: 401911-79-3
[(1R,4S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-cyclohepta-2,6-dienyl]-acetic acid methyl ester

: 328394-37-2
(3aS,4R,5R,6S,7R,8aR)-5,7-Dihydroxy-4,6-dimethyl-octahydro-cyclohepta[b]furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / TBAF / acetic acid; tetrahydrofuran / 60 h

2: 80 percent

With tetrabutyl ammonium fluoride; In tetrahydrofuran; acetic acid;
DOI:10.1021/ol0003836