(R_P)-O-isopropyl p-nitrophenyl methylphosphonate

Base Information

• Chemical Name: (R_P)-O-isopropyl p-nitrophenyl methylphosphonate
• CAS No.: 35921-06-3
• Molecular Formula: C₁₀H₁₄NO₅P
• Molecular Weight: 259.199
• Mol file: 35921-06-3.mol

Synonyms:(R_P)-O-isopropyl p-nitrophenyl methylphosphonate

Chemical Property of (R_P)-O-isopropyl p-nitrophenyl methylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R_P)-O-isopropyl p-nitrophenyl methylphosphonate

There total 2 articles about (R_P)-O-isopropyl p-nitrophenyl methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl-phosphonothioic acid O-isopropyl ester O-(4-nitro-phenyl) ester (369222-03-7) → (RP)-O-isopropyl p-nitrophenyl methylphosphonate (35921-06-3,152322-41-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/S0968-0896(01)00113-4

Reference yield: 77.0%

O,O-di-4-nitrophenyl methylphosphonate (6395-57-9) → (RP)-O-isopropyl p-nitrophenyl methylphosphonate (35921-06-3,152322-41-3)

Guidance literature:

With CHES buffer; H₂₅₇Y mutant enzyme; phosphotriesterase I₁₀₆A; In methanol; water; at 20 ℃; pH=9.0;

DOI:10.1016/S0968-0896(01)00113-4

Reference yield:

(RP)-O-isopropyl p-nitrophenyl methylphosphonate (35921-06-3,152322-41-3) → methyl-phosphonothioic acid O-isopropyl ester O-(4-nitro-phenyl) ester (369222-03-7)

Guidance literature:

With Lawessons reagent; In toluene; at 100 ℃; for 4h;

DOI:10.1021/acs.biochem.1c00361

upstream raw materials:

O,O-di-4-nitrophenyl methylphosphonate

methyl-phosphonothioic acid O-isopropyl ester O-(4-nitro-phenyl) ester

Downstream raw materials:

methyl-phosphonothioic acid O-isopropyl ester O-(4-nitro-phenyl) ester