tert-butyl (1R,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate

Base Information

• Chemical Name: tert-butyl (1R,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate
• CAS No.: 528523-46-8
• Molecular Formula: C₃₀H₃₉NO₄Si
• Molecular Weight: 505.729
• Mol file: 528523-46-8.mol

Synonyms:tert-butyl (1R,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate

Chemical Property of tert-butyl (1R,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (1R,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate

There total 3 articles about tert-butyl (1R,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) + ((1R,2R)-2-hydroxy-1-hydroxymethyl-2-phenylethyl)carbamic acid tert-butyl ester (1009093-14-4) → tert-butyl (1R,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate (528523-46-8)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 13.5h;

DOI:10.1016/S0960-894X(02)00888-0

Reference yield:

(1R,2R)-2-amino-1-phenylpropane-1,3-diol (46032-98-8) → tert-butyl (1R,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate (528523-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0.5 h

2: imidazole / dimethylformamide / 13.5 h / 20 - 60 °C

With 1H-imidazole; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00888-0

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (1R,2R)-1-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-hydroxy-2-phenylethylcarbamate (528523-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 0.5 h

2: imidazole / dimethylformamide / 13.5 h / 20 - 60 °C

With 1H-imidazole; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(02)00888-0

upstream raw materials:

tert-butylchlorodiphenylsilane

((1R,2R)-2-hydroxy-1-hydroxymethyl-2-phenylethyl)carbamic acid tert-butyl ester

di-tert-butyl dicarbonate

(1R,2R)-2-amino-1-phenylpropane-1,3-diol

Downstream raw materials:

C₃₃H₄₃NO₄Si

C₁₁H₁₈N₂O

tert-butyl (4R,5R)-4-(hydroxymethyl)-2,2-dimethyl-5-phenyl-1,3-oxazolidine-3-carboxylate

C₁₉H₃₀N₂O₃