(+/-)-2-<2-<(3RS,4SR)-N-benzyloxycarbonyl-3-ethyl-4-pipridyl>ethyl>-3-formylmethylindole

Base Information

Chemical Name:(+/-)-2-<2-<(3RS,4SR)-N-benzyloxycarbonyl-3-ethyl-4-pipridyl>ethyl>-3-formylmethylindole
CAS No.:104777-57-3
Molecular Formula:C₂₇H₃₂N₂O₃
Molecular Weight:432.563
Hs Code.:

Synonyms:(+/-)-2-<2-<(3RS,4SR)-N-benzyloxycarbonyl-3-ethyl-4-pipridyl>ethyl>-3-formylmethylindole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-2-<2-<(3RS,4SR)-N-benzyloxycarbonyl-3-ethyl-4-pipridyl>ethyl>-3-formylmethylindole

Chemical Property:

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Technology Process of (+/-)-2-<2-<(3RS,4SR)-N-benzyloxycarbonyl-3-ethyl-4-pipridyl>ethyl>-3-formylmethylindole

There total 10 articles about (+/-)-2-<2-<(3RS,4SR)-N-benzyloxycarbonyl-3-ethyl-4-pipridyl>ethyl>-3-formylmethylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 104777-76-6
(+/-)-2-<(3RS,4SR)-N-benzyloxycarbonyl-3-ethyl-4-piperidylethyl>-3-ethoxycarbonylmethylindole

: 104777-57-3
(+/-)-2-<2-<(3RS,4SR)-N-benzyloxycarbonyl-3-ethyl-4-pipridyl>ethyl>-3-formylmethylindole

Guidance literature:: With diisobutylaluminium hydride; In 1,2-dimethoxyethane; dichloromethane; at -78 ℃; for 0.166667h;

Reference yield:

: (+/-)-N-benzyloxycarbonyl-3-ethyl-4-piperidone

: 104777-57-3
(+/-)-2-<2-<(3RS,4SR)-N-benzyloxycarbonyl-3-ethyl-4-pipridyl>ethyl>-3-formylmethylindole

Guidance literature:: Multi-step reaction with 9 steps

1: NaH

2: H₂ / PtO₂

3: LiOH / methanol; H₂O

4: (COCl)2 / CH₂Cl₂

5: SnCl₄ / diethyl ether / 0.17 h / 0 °C

6: NaBH₄

7: AcOH / benzene / Heating

8: H₂ / PtO₂

9: 69 percent / DIBAL / CH₂Cl₂; 1,2-dimethoxy-ethane / -78 °C

With lithium hydroxide; sodium tetrahydroborate; oxalyl dichloride; hydrogen; tin(IV) chloride; sodium hydride; diisobutylaluminium hydride; acetic acid; platinum(IV) oxide; In methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; benzene;
DOI:10.1039/c39860000573

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 104777-57-3
(+/-)-2-<2-<(3RS,4SR)-N-benzyloxycarbonyl-3-ethyl-4-pipridyl>ethyl>-3-formylmethylindole

Guidance literature:: Multi-step reaction with 10 steps

1: NaHCO₃

2: NaH

3: H₂ / PtO₂

4: LiOH / methanol; H₂O

5: (COCl)2 / CH₂Cl₂

6: SnCl₄ / diethyl ether / 0.17 h / 0 °C

7: NaBH₄

8: AcOH / benzene / Heating

9: H₂ / PtO₂

10: 69 percent / DIBAL / CH₂Cl₂; 1,2-dimethoxy-ethane / -78 °C

With lithium hydroxide; sodium tetrahydroborate; oxalyl dichloride; hydrogen; tin(IV) chloride; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; acetic acid; platinum(IV) oxide; In methanol; 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; benzene;
DOI:10.1039/c39860000573