methyl (RS)-3-[((S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]-3-methyl-4-[methyl(phenyl)amino]-4-oxobutanoate

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Chemical Name:methyl (RS)-3-[((S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]-3-methyl-4-[methyl(phenyl)amino]-4-oxobutanoate
CAS No.:875153-24-5
Molecular Formula:C₂₆H₃₃N₃O₆
Molecular Weight:483.565
Hs Code.:

Synonyms:methyl (RS)-3-[((S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]-3-methyl-4-[methyl(phenyl)amino]-4-oxobutanoate

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Chemical Property of methyl (RS)-3-[((S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]-3-methyl-4-[methyl(phenyl)amino]-4-oxobutanoate

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Technology Process of methyl (RS)-3-[((S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]-3-methyl-4-[methyl(phenyl)amino]-4-oxobutanoate

There total 7 articles about methyl (RS)-3-[((S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]-3-methyl-4-[methyl(phenyl)amino]-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 875153-22-3
methyl 2-{2-methyl-3-[methyl(phenyl)amino]-2H-azirin-2-yl}ethanoate

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 875153-24-5
methyl (RS)-3-[((S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]-3-methyl-4-[methyl(phenyl)amino]-4-oxobutanoate

Guidance literature:: In dichloromethane; at 20 ℃; for 22h;
DOI:10.1002/hlca.200590238

Reference yield:

: 1123-19-9,112607-28-0,112607-29-1
3-acetyl-3-methyl-dihydro-furan-2-one

: 875153-24-5
methyl (RS)-3-[((S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]-3-methyl-4-[methyl(phenyl)amino]-4-oxobutanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 89 percent / EtONa / ethanol / 5 h / Heating

2.1: AlCl₃ / CH₂Cl₂ / 0 °C

2.2: 69 percent / CH₂Cl₂ / 5 h / 20 °C

3.1: 79 percent / NaIO₄ / RuCl₃*H₂O / acetonitrile; ethyl acetate; H₂O / 7 h / 20 °C

4.1: 100 percent / tetrahydrofuran; diethyl ether / 2.25 h / 0 - 20 °C

5.1: 89 percent / Lawesson's reagent / toluene / 0.58 h / 130 °C

6.1: COCl₂; DMF / CH₂Cl₂; toluene / 30 h / 0 °C

6.2: 1,4-diazabicyclo[2.2.2]octane / tetrahydrofuran / 0.33 h / 20 °C

6.3: 20 percent / NaN₃ / dimethylformamide / 144 h / 20 °C

7.1: 78 percent / CH₂Cl₂ / 22 h / 20 °C

With Lawessons reagent; sodium periodate; aluminium trichloride; sodium ethanolate; N,N-dimethyl-formamide; ruthenium trichloride; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile;
DOI:10.1002/hlca.200590238

Reference yield:

: 134750-60-0
4-hydroxy-2,N-dimethyl-N-phenylbutanamide

: 875153-24-5
methyl (RS)-3-[((S)-2-{[(benzyloxy)carbonyl]amino}-3-methyl-1-oxobutyl)amino]-3-methyl-4-[methyl(phenyl)amino]-4-oxobutanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 79 percent / NaIO₄ / RuCl₃*H₂O / acetonitrile; ethyl acetate; H₂O / 7 h / 20 °C

2.1: 100 percent / tetrahydrofuran; diethyl ether / 2.25 h / 0 - 20 °C

3.1: 89 percent / Lawesson's reagent / toluene / 0.58 h / 130 °C

4.1: COCl₂; DMF / CH₂Cl₂; toluene / 30 h / 0 °C

4.2: 1,4-diazabicyclo[2.2.2]octane / tetrahydrofuran / 0.33 h / 20 °C

4.3: 20 percent / NaN₃ / dimethylformamide / 144 h / 20 °C

5.1: 78 percent / CH₂Cl₂ / 22 h / 20 °C

With Lawessons reagent; sodium periodate; N,N-dimethyl-formamide; ruthenium trichloride; In tetrahydrofuran; diethyl ether; dichloromethane; water; ethyl acetate; toluene; acetonitrile;
DOI:10.1002/hlca.200590238