2-[2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-2-(2-nitro-benzenesulfonylamino)-propoxy]-2-methyl-propionicacid tert-butyl ester

Base Information

Chemical Name:2-[2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-2-(2-nitro-benzenesulfonylamino)-propoxy]-2-methyl-propionicacid tert-butyl ester
CAS No.:1262859-84-6
Molecular Formula:C₂₃H₂₆BrF₃N₂O₇S
Molecular Weight:611.434
Hs Code.:

Synonyms:2-[2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-2-(2-nitro-benzenesulfonylamino)-propoxy]-2-methyl-propionicacid tert-butyl ester

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Chemical Property of 2-[2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-2-(2-nitro-benzenesulfonylamino)-propoxy]-2-methyl-propionicacid tert-butyl ester

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Technology Process of 2-[2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-2-(2-nitro-benzenesulfonylamino)-propoxy]-2-methyl-propionicacid tert-butyl ester

There total 3 articles about 2-[2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-2-(2-nitro-benzenesulfonylamino)-propoxy]-2-methyl-propionicacid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262859-83-5
2-(5-bromo-2-fluorophenyl)-2-(difluoromethyl)-1-(2-nitrophenylsulfonyl)aziridine

: 36293-63-7
tert-butyl 2-hydroxy-2-methylpropanoate

: 1262859-84-6
2-[2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-2-(2-nitro-benzenesulfonylamino)-propoxy]-2-methyl-propionicacid tert-butyl ester

Guidance literature:: tert-butyl 2-hydroxy-2-methylpropanoate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

2-(5-bromo-2-fluorophenyl)-2-(difluoromethyl)-1-(2-nitrophenylsulfonyl)aziridine; In N,N-dimethyl-formamide; at 20 ℃; for 2.5h;

Reference yield:

: 1262941-31-0
2-Amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol

: 1262859-84-6
2-[2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-2-(2-nitro-benzenesulfonylamino)-propoxy]-2-methyl-propionicacid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydrogencarbonate / acetonitrile, 2-nitrobenzenesulfonyl chloride

2: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran

With sodium hydride; potassium hydrogencarbonate; In tetrahydrofuran; acetonitrile, 2-nitrobenzenesulfonyl chloride; N,N-dimethyl-formamide;

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1262859-84-6
2-[2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-2-(2-nitro-benzenesulfonylamino)-propoxy]-2-methyl-propionicacid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydrogencarbonate / acetonitrile / 80 °C

2: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide / 2.75 h / 20 °C

With sodium hydride; potassium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;