methyl 2-(4-bromo-2-fluorobenzyl)-4-(2-methoxy-2-oxoethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-carboxylate-1,1-dioxide

Base Information

Chemical Name:methyl 2-(4-bromo-2-fluorobenzyl)-4-(2-methoxy-2-oxoethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-carboxylate-1,1-dioxide
CAS No.:1432503-80-4
Molecular Formula:C₁₉H₁₈BrFN₂O₆S
Molecular Weight:501.33
Hs Code.:

Synonyms:methyl 2-(4-bromo-2-fluorobenzyl)-4-(2-methoxy-2-oxoethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-carboxylate-1,1-dioxide

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Chemical Property of methyl 2-(4-bromo-2-fluorobenzyl)-4-(2-methoxy-2-oxoethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-carboxylate-1,1-dioxide

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Technology Process of methyl 2-(4-bromo-2-fluorobenzyl)-4-(2-methoxy-2-oxoethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-carboxylate-1,1-dioxide

There total 8 articles about methyl 2-(4-bromo-2-fluorobenzyl)-4-(2-methoxy-2-oxoethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-carboxylate-1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1432503-75-7
methyl 4-(2-methoxy-2-oxoethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-carboxylate-1,1-dioxide

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 1432503-80-4
methyl 2-(4-bromo-2-fluorobenzyl)-4-(2-methoxy-2-oxoethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-carboxylate-1,1-dioxide

Guidance literature:: With potassium carbonate; In acetonitrile; at 70 ℃; for 2h;
DOI:10.1002/cmdc.201200386

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1432503-80-4
methyl 2-(4-bromo-2-fluorobenzyl)-4-(2-methoxy-2-oxoethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-carboxylate-1,1-dioxide

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitromethane / 0.5 h / -40 °C

1.2: 1 h / 110 °C

2.1: sodium hydroxide; potassium permanganate / water / 7 h / 0 - 80 °C

2.2: pH 1

3.1: sulfuric acid / water / 6 h / 140 °C

3.2: 0.5 h / 0 °C

4.1: 2 h / Reflux

5.1: sulfuric acid / 5 h / Reflux

6.1: potassium carbonate / acetonitrile / 2 h / 75 °C

7.1: sodium tetrahydroborate / methanol / 0.08 h

8.1: potassium carbonate / acetonitrile / 2 h / 70 °C

With sodium tetrahydroborate; potassium permanganate; sulfuric acid; potassium carbonate; sodium hydroxide; In methanol; nitromethane; water; acetonitrile;
DOI:10.1002/cmdc.201200386

Reference yield:

: 201224-76-2
3-oxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-carboxylic acid 1,1-dioxide

: 1432503-80-4
methyl 2-(4-bromo-2-fluorobenzyl)-4-(2-methoxy-2-oxoethyl)-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-carboxylate-1,1-dioxide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / water / 6 h / 140 °C

1.2: 0.5 h / 0 °C

2.1: 2 h / Reflux

3.1: sulfuric acid / 5 h / Reflux

4.1: potassium carbonate / acetonitrile / 2 h / 75 °C

5.1: sodium tetrahydroborate / methanol / 0.08 h

6.1: potassium carbonate / acetonitrile / 2 h / 70 °C

With sodium tetrahydroborate; sulfuric acid; potassium carbonate; In methanol; water; acetonitrile;
DOI:10.1002/cmdc.201200386