2-<(1'S)-2'-Diphenylphosphinoyl-1'-hydroxy-1'-phenylethyl>-3-phenyl-1,3-diazabicyclo<3.3.0>octane

Base Information

• Chemical Name: 2-<(1'S)-2'-Diphenylphosphinoyl-1'-hydroxy-1'-phenylethyl>-3-phenyl-1,3-diazabicyclo<3.3.0>octane
• CAS No.: 165879-52-7
• Molecular Formula: C₃₂H₃₃N₂O₂P
• Molecular Weight: 508.6

Synonyms:2-<(1'S)-2'-Diphenylphosphinoyl-1'-hydroxy-1'-phenylethyl>-3-phenyl-1,3-diazabicyclo<3.3.0>octane

Chemical Property of 2-<(1'S)-2'-Diphenylphosphinoyl-1'-hydroxy-1'-phenylethyl>-3-phenyl-1,3-diazabicyclo<3.3.0>octane

Chemical Property:

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Technology Process of 2-<(1'S)-2'-Diphenylphosphinoyl-1'-hydroxy-1'-phenylethyl>-3-phenyl-1,3-diazabicyclo<3.3.0>octane

There total 2 articles about 2-<(1'S)-2'-Diphenylphosphinoyl-1'-hydroxy-1'-phenylethyl>-3-phenyl-1,3-diazabicyclo<3.3.0>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

(+)-(benzoyl)-2 phenyl-3 diazabicyclo-1,3 <3,3,O> octane (165879-50-5) + diphenyl(methyl)phosphine oxide (2129-89-7) → 2-<(1'S)-2'-Diphenylphosphinoyl-1'-hydroxy-1'-phenylethyl>-3-phenyl-1,3-diazabicyclo<3.3.0>octane (165879-52-7) + 2-<(1'R)-2'-Diphenylphosphinoyl-1'-hydroxy-1'-phenylethyl>-3-phenyl-1,3-diazabicyclo<3.3.0>octane (165557-44-8)

Guidance literature:

With methyllithium; In diethyl ether; 1.) 0 deg C, 30 min, 2.) -78 deg C, 1.5 h;

DOI:10.1039/P19960002117

Reference yield:

lithiated methyldiphenylphosphine oxide (23182-99-2) + (+)-(benzoyl)-2 phenyl-3 diazabicyclo-1,3 <3,3,O> octane (165879-50-5) → 2-<(1'S)-2'-Diphenylphosphinoyl-1'-hydroxy-1'-phenylethyl>-3-phenyl-1,3-diazabicyclo<3.3.0>octane (165879-52-7) + 2-<(1'R)-2'-Diphenylphosphinoyl-1'-hydroxy-1'-phenylethyl>-3-phenyl-1,3-diazabicyclo<3.3.0>octane (165557-44-8)

Guidance literature:

In tetrahydrofuran; at -78 ℃; Product distribution; with different metal and solvent;

DOI:10.1016/0040-4039(95)00334-9

Reference yield: 65.0%

2-<(1'S)-2'-Diphenylphosphinoyl-1'-hydroxy-1'-phenylethyl>-3-phenyl-1,3-diazabicyclo<3.3.0>octane (165879-52-7) → (S)-3-Diphenylphosphinoyl-2-hydroxy-2-phenylpropanal (165557-47-1)

Guidance literature:

With hydrogenchloride; In dichloromethane;

DOI:10.1016/0040-4039(95)00334-9

upstream raw materials:

lithiated methyldiphenylphosphine oxide

(+)-(benzoyl)-2 phenyl-3 diazabicyclo-1,3 <3,3,O> octane

diphenyl(methyl)phosphine oxide

Downstream raw materials:

(S)-3-Diphenylphosphinoyl-2-hydroxy-2-phenylpropanal

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