13-(2-fluorobenzyl)-9,10-dimethoxy-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline-7-iumbromide

Base Information

Chemical Name:13-(2-fluorobenzyl)-9,10-dimethoxy-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline-7-iumbromide
CAS No.:1390654-28-0
Molecular Formula:Br*C₂₇H₂₃FNO₄
Molecular Weight:524.386
Hs Code.:

Synonyms:13-(2-fluorobenzyl)-9,10-dimethoxy-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline-7-iumbromide

Suppliers and Price of 13-(2-fluorobenzyl)-9,10-dimethoxy-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline-7-iumbromide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 13-(2-fluorobenzyl)-9,10-dimethoxy-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline-7-iumbromide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Pictogram(s):
Hazard Codes:

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Technology Process of 13-(2-fluorobenzyl)-9,10-dimethoxy-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline-7-iumbromide

There total 3 articles about 13-(2-fluorobenzyl)-9,10-dimethoxy-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline-7-iumbromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 446-48-0
o-fluorobenzyl bromide

: 483-15-8
7,8-dihydroberberine

: 1390654-28-0
13-(2-fluorobenzyl)-9,10-dimethoxy-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline-7-iumbromide

Guidance literature:: With potassium iodide; In acetonitrile; for 4h; Reflux;
DOI:10.1002/cmdc.201300332

Reference yield: 45.0%

: 446-48-0
o-fluorobenzyl bromide

: 39024-13-0
acetoneberberine

: 1390654-28-0
13-(2-fluorobenzyl)-9,10-dimethoxy-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline-7-iumbromide

Guidance literature:: With sodium iodide; In acetonitrile; at 80 ℃; for 4h;

Reference yield:

: 633-65-8
berberine chloride

: 1390654-28-0
13-(2-fluorobenzyl)-9,10-dimethoxy-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline-7-iumbromide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate; potassium carbonate; sodium hydroxide / methanol / 1 h / 20 °C

2: potassium iodide / acetonitrile / 4 h / Reflux

With sodium tetrahydroborate; potassium carbonate; potassium iodide; sodium hydroxide; In methanol; acetonitrile;
DOI:10.1002/cmdc.201300332