15-(t-butyldiphenylsilyl) PGF_2α

Base Information

Chemical Name:15-(t-butyldiphenylsilyl) PGF_2α
CAS No.:118908-08-0
Molecular Formula:C₃₆H₅₂O₅Si
Molecular Weight:592.891
Hs Code.:

15-(t-butyldiphenylsilyl) PGF<sub>2α</sub>

Synonyms:15-(t-butyldiphenylsilyl) PGF_2α

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 15-(t-butyldiphenylsilyl) PGF_2α

Chemical Property:

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Technology Process of 15-(t-butyldiphenylsilyl) PGF_2α

There total 11 articles about 15-(t-butyldiphenylsilyl) PGF_2α which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32233-40-2
(3aR,4S,5R,6aS)-5-hydroxy-4-(hydroxymethyl)hexahydro-2H-cyclopenta[b]furan-2-one

: 118908-08-0
15-(t-butyldiphenylsilyl) PGF_2α

Guidance literature:: Multi-step reaction with 11 steps

1: pyridine / 48 h / -18 °C

2: 1) t-BuOK / 1) DMSO, RT, 2) DMSO, 30 min

3: DIBAL / toluene; CH₂Cl₂ / 0.5 h / -78 °C

4: BF₃*Et₂O / 2 h / -20 °C

5: imidazole / dimethylformamide / 0.17 h / 40 °C

6: 80percent m-chloroperbenzoic acid / CH₂Cl₂ / 1) -78 to 0 deg C, 30 min,2) 0 deg C,2 h

7: 1) n-butyllithium, 2) BF₃*Et₂O / 1) THF, hexane, -78 deg C, 5 min,2) THF, hexane, 10 min, 3) THF, hexane, -30 deg C, 2 h

8: pyridine / 15 h / Ambient temperature

9: 6percent sodium amalgam / tetrahydrofuran; methanol / 3 h / Ambient temperature

10: 77 percent / 0.3N hydrochloric acid / acetonitrile / 2 h

11: 1) t-BuOK / 1) THF, 2) THF, 30 min

With pyridine; 1H-imidazole; hydrogenchloride; sodium amalgam; n-butyllithium; boron trifluoride diethyl etherate; potassium tert-butylate; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/S0040-4020(01)86203-7

Reference yield:

: 118888-95-2,119008-06-9
(3aR,4R,5R,6aS)-5-(tert-Butyl-dimethyl-silanyloxy)-4-[(E)-(S)-3-(tert-butyl-diphenyl-silanyloxy)-oct-1-enyl]-2-methoxy-hexahydro-cyclopenta[b]furan

: 118908-08-0
15-(t-butyldiphenylsilyl) PGF_2α

Guidance literature:: Multi-step reaction with 2 steps

1: 77 percent / 0.3N hydrochloric acid / acetonitrile / 2 h

2: 1) t-BuOK / 1) THF, 2) THF, 30 min

With hydrogenchloride; potassium tert-butylate; In acetonitrile;
DOI:10.1016/S0040-4020(01)86203-7

Reference yield:

: 118888-93-0
(S)-1-Benzenesulfonyl-1-[(3aR,4R,5R,6aS)-5-(tert-butyl-dimethyl-silanyloxy)-2-methoxy-hexahydro-cyclopenta[b]furan-4-yl]-3-(tert-butyl-diphenyl-silanyloxy)-octan-2-ol

: 118908-08-0
15-(t-butyldiphenylsilyl) PGF_2α

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 15 h / Ambient temperature

2: 6percent sodium amalgam / tetrahydrofuran; methanol / 3 h / Ambient temperature

3: 77 percent / 0.3N hydrochloric acid / acetonitrile / 2 h

4: 1) t-BuOK / 1) THF, 2) THF, 30 min

With pyridine; hydrogenchloride; sodium amalgam; potassium tert-butylate; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/S0040-4020(01)86203-7