(S)-2-(N-fluorenylmethoxycarbonylamino)-3-phenyl-iodopropane

Base Information

• Chemical Name: (S)-2-(N-fluorenylmethoxycarbonylamino)-3-phenyl-iodopropane
• CAS No.: 161529-17-5
• Molecular Formula: C₂₄H₂₂INO₂
• Molecular Weight: 483.349
• Mol file: 161529-17-5.mol

Synonyms:(S)-2-(N-fluorenylmethoxycarbonylamino)-3-phenyl-iodopropane

Chemical Property of (S)-2-(N-fluorenylmethoxycarbonylamino)-3-phenyl-iodopropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(N-fluorenylmethoxycarbonylamino)-3-phenyl-iodopropane

There total 3 articles about (S)-2-(N-fluorenylmethoxycarbonylamino)-3-phenyl-iodopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(9-fluorenylmethoxycarbonyl)-L-phenylalaninol (129397-83-7) → (S)-2-(N-fluorenylmethoxycarbonylamino)-3-phenyl-iodopropane (161529-17-5)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 20 ℃;

DOI:10.1055/s-2005-923589

Reference yield:

L-Phenylalaninol (3182-95-4) → (S)-2-(N-fluorenylmethoxycarbonylamino)-3-phenyl-iodopropane (161529-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 10 percent aq. Na₂CO₃ / tetrahydrofuran / 2 h / pH 9

2: 94 percent / polystyryl diphenylphosphine, imidazole, iodine / CH₂Cl₂ / 1 h / Heating

With 1H-imidazole; diphenylphosphinopolystyrene; iodine; sodium carbonate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4020(95)00778-7

Reference yield:

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → (S)-2-(N-fluorenylmethoxycarbonylamino)-3-phenyl-iodopropane (161529-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 10 percent aq. Na₂CO₃ / tetrahydrofuran / 2 h / pH 9

2: 94 percent / polystyryl diphenylphosphine, imidazole, iodine / CH₂Cl₂ / 1 h / Heating

With 1H-imidazole; diphenylphosphinopolystyrene; iodine; sodium carbonate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/0040-4020(95)00778-7

upstream raw materials:

(9-fluorenylmethoxycarbonyl)-L-phenylalaninol

L-Phenylalaninol

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

Fmoc-Phe-N₃

C₃₆H₄₃N₃O₄S₄

(9H-fluoren-9-yl)methyl (S)-3-phenyl-1-thiocyanatopropan-2-ylcarbamate

(9H-fluoren-9-yl)methyl (S)-3-phenyl-1-(2H-tetrazol-5-ylthio)propan-2-ylcarbamate