5-Pyrimidinepropanoic acid, alpha-aminohexahydro-1-methyl-2,4-dioxo-, (alphaS,5S)- (9CI)

Base Information

Chemical Name:5-Pyrimidinepropanoic acid, alpha-aminohexahydro-1-methyl-2,4-dioxo-, (alphaS,5S)- (9CI)
CAS No.:326891-09-2
Molecular Formula:C₈H₁₃N₃O₄
Molecular Weight:215.209
Hs Code.:
Mol file:326891-09-2.mol

Synonyms:5-Pyrimidinepropanoic acid, alpha-aminohexahydro-1-methyl-2,4-dioxo-, (alphaS,5S)- (9CI)

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Chemical Property of 5-Pyrimidinepropanoic acid, alpha-aminohexahydro-1-methyl-2,4-dioxo-, (alphaS,5S)- (9CI)

Chemical Property:

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Technology Process of 5-Pyrimidinepropanoic acid, alpha-aminohexahydro-1-methyl-2,4-dioxo-, (alphaS,5S)- (9CI)

There total 6 articles about 5-Pyrimidinepropanoic acid, alpha-aminohexahydro-1-methyl-2,4-dioxo-, (alphaS,5S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: benzyl (2S,5'RS)-2-benzyloxycarbonylamino-3-(1-methyl-2,4-dioxohexahydropyrimidin-5-yl)propionate

: 326891-09-2
(2S,5'RS)-2-amino-3-(1-methyl-2,4-dioxohexahydropyrimidin-5-yl)propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; at 20 ℃; for 1h;

Reference yield:

: 134174-76-8
benzyl (2S)-1-benzyloxycarbonyl-4-dimethylaminomethylenepyroglutamate

: 326891-09-2
(2S,5'RS)-2-amino-3-(1-methyl-2,4-dioxohexahydropyrimidin-5-yl)propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: aq. HCl / methanol / 0.5 h / 20 °C

2: aq. methanol / 0.25 h / 20 °C

3: 99 percent / NaBH₄ / acetic acid / 0.42 h

4: 86 percent / AcOH / methanol / 16 h / 20 °C

5: 90 percent / NaH / tetrahydrofuran / 0.5 h / 20 °C

6: H₂ / 10 percent Pd/C / acetic acid / 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; hydrogen; sodium hydride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;

Reference yield:

: 326890-92-0
(E)-benzyl (2S)-N-benzyloxycarbonyl-4-N-methylaminomethylenepyroglutamate

: 326891-09-2
(2S,5'RS)-2-amino-3-(1-methyl-2,4-dioxohexahydropyrimidin-5-yl)propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / NaBH₄ / acetic acid / 0.42 h

2: 86 percent / AcOH / methanol / 16 h / 20 °C

3: 90 percent / NaH / tetrahydrofuran / 0.5 h / 20 °C

4: H₂ / 10 percent Pd/C / acetic acid / 1 h / 20 °C

With sodium tetrahydroborate; hydrogen; sodium hydride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; acetic acid;