tert-butyl 4-[2-[(4-methanesulfonylphenylamino)-methyl]pyridin-5-yl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-[2-[(4-methanesulfonylphenylamino)-methyl]pyridin-5-yl]piperidine-1-carboxylate
CAS No.:1206968-46-8
Molecular Formula:C₂₃H₃₁N₃O₄S
Molecular Weight:445.583
Hs Code.:

Synonyms:tert-butyl 4-[2-[(4-methanesulfonylphenylamino)-methyl]pyridin-5-yl]piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-[2-[(4-methanesulfonylphenylamino)-methyl]pyridin-5-yl]piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-[2-[(4-methanesulfonylphenylamino)-methyl]pyridin-5-yl]piperidine-1-carboxylate

There total 7 articles about tert-butyl 4-[2-[(4-methanesulfonylphenylamino)-methyl]pyridin-5-yl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3466-32-8
4-bromoohenyl methyl sulfone

: 1206968-96-8
tert-butyl 4-[(2-aminomethyl)pyridin-5-yl]-piperidine-1-carboxylate

: 1206968-46-8
tert-butyl 4-[2-[(4-methanesulfonylphenylamino)-methyl]pyridin-5-yl]piperidine-1-carboxylate

Guidance literature:: With potassium hydroxide; 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In tert-Amyl alcohol; water; at 100 ℃;

Reference yield:

: 286961-15-7
benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1 (2H)-pyridinecarboxylate

: 1206968-46-8
tert-butyl 4-[2-[(4-methanesulfonylphenylamino)-methyl]pyridin-5-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; tetrahydrofuran / 2.5 h / 90 °C / Inert atmosphere

2: hydrogen / palladium 10% on activated carbon / methanol / 17 h / 20 °C

3: triethylamine / water; tetrahydrofuran / 0.17 h / 20 °C

4: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 25 h / 0 - 20 °C / Inert atmosphere

5: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C

6: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium(0); 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole / water; tert-Amyl alcohol / 100 °C

With diphenyl phosphoryl azide; hydrogen; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; potassium hydroxide; 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tert-Amyl alcohol; water; N,N-dimethyl-formamide;

Reference yield:

: 1206968-57-1
4-[2-(hydroxymethyl)pyridin-5-yl]-1H-piperidine

: 1206968-46-8
tert-butyl 4-[2-[(4-methanesulfonylphenylamino)-methyl]pyridin-5-yl]piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / water; tetrahydrofuran / 0.17 h / 20 °C

2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 25 h / 0 - 20 °C / Inert atmosphere

3: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C

4: potassium hydroxide / tris-(dibenzylideneacetone)dipalladium(0); 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole / water; tert-Amyl alcohol / 100 °C

With diphenyl phosphoryl azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; potassium hydroxide; 5-(di-tert-butylphosphino)-1′, 3′, 5′-triphenyl-1′H-[1,4′]bipyrazole; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; In tetrahydrofuran; methanol; tert-Amyl alcohol; water;