2-(dimethylamino)ethyl 4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate mono trifluoroacetic acid

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Chemical Name:2-(dimethylamino)ethyl 4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate mono trifluoroacetic acid
CAS No.:1000183-42-5
Molecular Formula:C₂HF₃O₂*C₂₇H₃₀FN₇O₂
Molecular Weight:617.603
Hs Code.:

Synonyms:2-(dimethylamino)ethyl 4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate mono trifluoroacetic acid

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Chemical Property of 2-(dimethylamino)ethyl 4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate mono trifluoroacetic acid

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Technology Process of 2-(dimethylamino)ethyl 4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate mono trifluoroacetic acid

There total 11 articles about 2-(dimethylamino)ethyl 4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate mono trifluoroacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1000183-41-4
2-(dimethylamino)ethyl 4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1000183-42-5
2-(dimethylamino)ethyl 4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate mono trifluoroacetic acid

Guidance literature:: In water; acetonitrile;

Reference yield:

: 399-52-0
5-fluoro-1H-indole

: 1000183-42-5
2-(dimethylamino)ethyl 4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate mono trifluoroacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; triethylamine / dichloromethane / 12 h

2.1: N-Bromosuccinimide / dichloromethane / 12 h

3.1: Triisopropyl borate; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C

3.2: 2.5 h / 20 °C

3.3: 0.5 h

4.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C

5.1: 1,4-dioxane / 12 h / 150 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: water; acetonitrile

With dmap; N-Bromosuccinimide; Triisopropyl borate; sec.-butyllithium; sodium hydrogencarbonate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water; acetonitrile;

Reference yield:

: 1000183-46-9
3-bromo-5-fluoro-1-Boc-1H-indole

: 1000183-42-5
2-(dimethylamino)ethyl 4-(4-{[4-(5-fluoro-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)piperazine-1-carboxylate mono trifluoroacetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: Triisopropyl borate; sec.-butyllithium / tetrahydrofuran; cyclohexane / 1 h / -78 °C

1.2: 2.5 h / 20 °C

1.3: 0.5 h

2.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 80 °C

3.1: 1,4-dioxane / 12 h / 150 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.1: water; acetonitrile

With Triisopropyl borate; sec.-butyllithium; sodium hydrogencarbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; water; acetonitrile;