5'-O--5-<3-<<2-<<<1--1H-imidazol-4-yl>acetyl>amino>ethyl>amino>-3-oxopropyl>-2'-deoxyuridine

Base Information

• Chemical Name: 5'-O--5-<3-<<2-<<<1--1H-imidazol-4-yl>acetyl>amino>ethyl>amino>-3-oxopropyl>-2'-deoxyuridine
• CAS No.: 128870-23-5
• Molecular Formula: C₆₁H₆₂N₆O₁₁
• Molecular Weight: 1055.2
• Mol file: 128870-23-5.mol

Synonyms:5'-O--5-<3-<<2-<<<1--1H-imidazol-4-yl>acetyl>amino>ethyl>amino>-3-oxopropyl>-2'-deoxyuridine

Chemical Property of 5'-O--5-<3-<<2-<<<1--1H-imidazol-4-yl>acetyl>amino>ethyl>amino>-3-oxopropyl>-2'-deoxyuridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O--5-<3-<<2-<<<1--1H-imidazol-4-yl>acetyl>amino>ethyl>amino>-3-oxopropyl>-2'-deoxyuridine

There total 6 articles about 5'-O--5-<3-<<2-<<<1--1H-imidazol-4-yl>acetyl>amino>ethyl>amino>-3-oxopropyl>-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide (128870-19-9) + 5'-O--2'-deoxyuridine-5-propionic acid p-nitrophenylester (128870-22-4) → 5'-O--5-<3-<<2-<<<1--1H-imidazol-4-yl>acetyl>amino>ethyl>amino>-3-oxopropyl>-2'-deoxyuridine (128870-23-5)

Guidance literature:

With triethylamine; In dichloromethane; for 8h; Ambient temperature;

DOI:10.1021/jo00304a026

Reference yield:

imidazole-4-acetic acid hydrochloride (3251-69-2) → 5'-O--5-<3-<<2-<<<1--1H-imidazol-4-yl>acetyl>amino>ethyl>amino>-3-oxopropyl>-2'-deoxyuridine (128870-23-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / conc. H₂SO₄ / 12 h / Heating

2: 76 percent / Et₃N / CH₂Cl₂

3: 91 percent / 48 h / Ambient temperature

4: 63 percent / Et₃N / CH₂Cl₂ / 8 h / Ambient temperature

With sulfuric acid; triethylamine; In dichloromethane;

DOI:10.1021/jo00304a026

Reference yield:

5-(2-carbethoxyethyl)-2'-deoxyuridine (128870-20-2) → 5'-O--5-<3-<<2-<<<1--1H-imidazol-4-yl>acetyl>amino>ethyl>amino>-3-oxopropyl>-2'-deoxyuridine (128870-23-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 79 percent / DCC / dimethylformamide / 1) 0 deg C, 30 min 2) r.t., 6h

2: 70 percent / pyridine / 4 h

3: 63 percent / Et₃N / CH₂Cl₂ / 8 h / Ambient temperature

With pyridine; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo00304a026

upstream raw materials:

N-(2-Aminoethyl)-1--1H-imidazole-4-acetamide

5'-O--2'-deoxyuridine-5-propionic acid p-nitrophenylester

imidazole-4-acetic acid hydrochloride

5-(2-carbethoxyethyl)-2'-deoxyuridine