1,2-bis(1,5-dimethyl-2-phenylpyrrol-4-yl)perfluorocyclopentene

Base Information

• Chemical Name: 1,2-bis(1,5-dimethyl-2-phenylpyrrol-4-yl)perfluorocyclopentene
• CAS No.: 313055-81-1
• Molecular Formula: C₂₉H₂₄F₆N₂
• Molecular Weight: 514.513
• Mol file: 313055-81-1.mol

Synonyms:1,2-bis(1,5-dimethyl-2-phenylpyrrol-4-yl)perfluorocyclopentene

Chemical Property of 1,2-bis(1,5-dimethyl-2-phenylpyrrol-4-yl)perfluorocyclopentene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-bis(1,5-dimethyl-2-phenylpyrrol-4-yl)perfluorocyclopentene

There total 8 articles about 1,2-bis(1,5-dimethyl-2-phenylpyrrol-4-yl)perfluorocyclopentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

1,2-bis(2-iodo-1,5-dimethylpyrrol-4-yl)perfluorocyclopentene (638174-11-5) + phenylboronic acid (98-80-6) → 1,2-bis(1,5-dimethyl-2-phenylpyrrol-4-yl)perfluorocyclopentene (313055-81-1)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; at 70 ℃; for 18h;

DOI:10.1039/b302623j

Reference yield:

1,2-bis(2-methoxycarbonyl-1,5-dimethylpyrrol-4-yl)perfluorocyclopentene (638174-07-9) → 1,2-bis(1,5-dimethyl-2-phenylpyrrol-4-yl)perfluorocyclopentene (313055-81-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / aq. NaOH / methanol / 1.5 h / Heating

2: 95 percent / I₂; KI; NaHCO₃ / methanol; H₂O / 5 h / 60 °C

3: 52 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; ethanol / 18 h / 70 °C

With sodium hydroxide; iodine; sodium hydrogencarbonate; sodium carbonate; potassium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; ethanol; water; 3: Suzuki coupling;

DOI:10.1039/b302623j

Reference yield:

1,2-bis(2-carboxy-1,5-dimethylpyrrol-4-yl)perflurocyclopentene (638174-09-1) → 1,2-bis(1,5-dimethyl-2-phenylpyrrol-4-yl)perfluorocyclopentene (313055-81-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / I₂; KI; NaHCO₃ / methanol; H₂O / 5 h / 60 °C

2: 52 percent / aq. Na₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane; ethanol / 18 h / 70 °C

With iodine; sodium hydrogencarbonate; sodium carbonate; potassium iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; ethanol; water; 2: Suzuki coupling;

DOI:10.1039/b302623j

upstream raw materials:

1,2-bis(2-iodo-1,5-dimethylpyrrol-4-yl)perfluorocyclopentene

phenylboronic acid

1,2-bis(2-methoxycarbonyl-1,5-dimethylpyrrol-4-yl)perfluorocyclopentene

1,2-bis(2-carboxy-1,5-dimethylpyrrol-4-yl)perflurocyclopentene