C₂₄H₂₅FN₂O₂

Base Information

Chemical Name:C₂₄H₂₅FN₂O₂
CAS No.:950524-63-7
Molecular Formula:C₂₄H₂₅FN₂O₂
Molecular Weight:392.473
Hs Code.:

C<sub>24</sub>H<sub>25</sub>FN<sub>2</sub>O<sub>2</sub>

Synonyms:C₂₄H₂₅FN₂O₂

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Chemical Property of C₂₄H₂₅FN₂O₂

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Technology Process of C₂₄H₂₅FN₂O₂

There total 10 articles about C₂₄H₂₅FN₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 950524-61-5
C₂₄H₂₃FN₂O₂

: 950524-63-7
C₂₄H₂₅FN₂O₂

Guidance literature:: With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1016/j.bmcl.2007.05.097

Reference yield:

: 950524-24-0
C₁₂H₁₂FNO₂

: 950524-63-7
C₂₄H₂₅FN₂O₂

Guidance literature:: Multi-step reaction with 7 steps

1: 92 percent / DBU / tetrahydrofuran / 18 h / 25 °C

2: 75 percent / KOH / dimethylsulfoxide / 2 h / 25 °C

3: 52 percent / NaIO₄; OsO₄ / tetrahydrofuran; H₂O / 18 h / 0 - 25 °C

4: 79 percent / Na(OAc)3BH; AcOH / 1,2-dichloro-ethane / 18 h / 25 °C

5: 94 percent / trimethylaluminum; triethylamine / CH₂Cl₂; toluene / 16 h / 60 °C

6: 97 percent / POCl₃ / 1,2-dichloro-ethane / 18 h / 80 °C

7: 56 percent / LiAl(O-t-Bu)3H / tetrahydrofuran / 0.5 h / 0 °C

With potassium hydroxide; sodium periodate; osmium(VIII) oxide; trimethylaluminum; sodium tris(acetoxy)borohydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium tri-t-butoxyaluminum hydride; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; 6: Vilsmeier-Haack formylation;
DOI:10.1016/j.bmcl.2007.05.097

Reference yield:

: 950524-22-8
C₁₂H₁₄FNO₃

: 950524-63-7
C₂₄H₂₅FN₂O₂

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / trifluoroacetic anhydride; triethylamine / CH₂Cl₂ / 0.5 h / -10 °C

2: 92 percent / DBU / tetrahydrofuran / 18 h / 25 °C

3: 75 percent / KOH / dimethylsulfoxide / 2 h / 25 °C

4: 52 percent / NaIO₄; OsO₄ / tetrahydrofuran; H₂O / 18 h / 0 - 25 °C

5: 79 percent / Na(OAc)3BH; AcOH / 1,2-dichloro-ethane / 18 h / 25 °C

6: 94 percent / trimethylaluminum; triethylamine / CH₂Cl₂; toluene / 16 h / 60 °C

7: 97 percent / POCl₃ / 1,2-dichloro-ethane / 18 h / 80 °C

8: 56 percent / LiAl(O-t-Bu)3H / tetrahydrofuran / 0.5 h / 0 °C

With potassium hydroxide; sodium periodate; osmium(VIII) oxide; trimethylaluminum; sodium tris(acetoxy)borohydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium tri-t-butoxyaluminum hydride; triethylamine; trifluoroacetic anhydride; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; 1,2-dichloro-ethane; toluene; 7: Vilsmeier-Haack formylation;
DOI:10.1016/j.bmcl.2007.05.097