N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-morpholinopropanamide

Base Information

Chemical Name:N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-morpholinopropanamide
CAS No.:1360430-68-7
Molecular Formula:C₃₁H₃₁ClN₆O₄
Molecular Weight:587.078
Hs Code.:

Synonyms:N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-morpholinopropanamide

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Chemical Property of N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-morpholinopropanamide

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Technology Process of N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-morpholinopropanamide

There total 12 articles about N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-morpholinopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 110-91-8,99108-56-2
morpholine

: 1233953-82-6
3-chloro-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide

: 1360430-68-7
N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-morpholinopropanamide

Guidance literature:: morpholine; 3-chloro-N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)propanamide; With potassium iodide; In ethanol; for 8.25h; Reflux;

With potassium hydroxide; In ethanol; at 0 ℃; for 1h;
DOI:10.1021/jm201507x

Reference yield:

: 848133-76-6
7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile

: 1360430-68-7
N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-morpholinopropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine hydrochloride / isopropyl alcohol / Reflux

2.1: hydrogenchloride / water / 5 h / Reflux

3.1: 50 °C

4.1: potassium iodide / ethanol / 8.25 h / Reflux

4.2: 1 h / 0 °C

With hydrogenchloride; pyridine hydrochloride; potassium iodide; In ethanol; water; isopropyl alcohol;
DOI:10.1021/jm201507x

Reference yield:

: 3964-52-1
2-chloro 4-aminophenol

: 1360430-68-7
N-(4-(3-chloro-4-(pyridin-2-ylmethoxy)anilino)-3-cyano-7-ethoxyquinolin-6-yl)-3-morpholinopropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzaldehyde / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 24 h / 50 °C

2.1: pyridine hydrochloride / isopropyl alcohol / Reflux

3.1: hydrogenchloride / water / 5 h / Reflux

4.1: 50 °C

5.1: potassium iodide / ethanol / 8.25 h / Reflux

5.2: 1 h / 0 °C

With hydrogenchloride; pyridine hydrochloride; benzaldehyde; potassium iodide; In ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm201507x