(E)-3-(2,5-Bis-benzyloxy-phenyl)-but-2-enoic acid ethyl ester

Base Information

• Chemical Name: (E)-3-(2,5-Bis-benzyloxy-phenyl)-but-2-enoic acid ethyl ester
• CAS No.: 131636-93-6
• Molecular Formula: C₂₆H₂₆O₄
• Molecular Weight: 402.49
• Mol file: 131636-93-6.mol

Synonyms:(E)-3-(2,5-Bis-benzyloxy-phenyl)-but-2-enoic acid ethyl ester

Chemical Property of (E)-3-(2,5-Bis-benzyloxy-phenyl)-but-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(2,5-Bis-benzyloxy-phenyl)-but-2-enoic acid ethyl ester

There total 3 articles about (E)-3-(2,5-Bis-benzyloxy-phenyl)-but-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-Dihydroxyacetophenone (490-78-8) → (E)-3-(2,5-Bis-benzyloxy-phenyl)-but-2-enoic acid ethyl ester (131636-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / K₂CO₃ / ethanol / 18 h / Heating

2: 1.) KOtBu / 1.) THF, r.t., 1h, 2.) benzene, reflux, 10h

With potassium tert-butylate; potassium carbonate; In ethanol;

DOI:10.1021/jo00004a008

Reference yield:

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 1-[2',5'-bis(phenylmethoxy)phenyl]ethanone (21766-81-4) → ethyl 3-(2,5-dibenzyloxyphenyl)crotonate (131637-05-3) + (E)-3-(2,5-Bis-benzyloxy-phenyl)-but-2-enoic acid ethyl ester (131636-93-6)

Guidance literature:

With potassium tert-butylate; Yield given. Multistep reaction. Yields of byproduct given; 1.) THF, r.t., 1h, 2.) benzene, reflux, 10h;

DOI:10.1021/jo00004a008

Reference yield:

benzyl chloride (100-44-7) → (E)-3-(2,5-Bis-benzyloxy-phenyl)-but-2-enoic acid ethyl ester (131636-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / K₂CO₃ / ethanol / 18 h / Heating

2: 1.) KOtBu / 1.) THF, r.t., 1h, 2.) benzene, reflux, 10h

With potassium tert-butylate; potassium carbonate; In ethanol;

DOI:10.1021/jo00004a008

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

1-[2',5'-bis(phenylmethoxy)phenyl]ethanone

benzyl chloride

2,5-Dihydroxyacetophenone

Downstream raw materials:

(2S,4R,5S)-5-(2,5-Bis-benzyloxy-phenyl)-5-methyl-2-phenyl-[1,3]dioxolane-4-carboxylic acid ethyl ester

(2R,4R,5S)-5-(2,5-Bis-benzyloxy-phenyl)-5-methyl-2-phenyl-[1,3]dioxolane-4-carboxylic acid ethyl ester

(2R,3S)-3-(2,5-Bis-benzyloxy-phenyl)-2,3-dihydroxy-butyric acid ethyl ester