(2R,3S,4R,5S)-trimethyl 5-(4-cyanophenyl)pyrrolidine-2,3,4-tricarboxylate

Base Information

Chemical Name:(2R,3S,4R,5S)-trimethyl 5-(4-cyanophenyl)pyrrolidine-2,3,4-tricarboxylate
CAS No.:1093167-95-3
Molecular Formula:C₁₇H₁₈N₂O₆
Molecular Weight:346.34
Hs Code.:

Synonyms:(2R,3S,4R,5S)-trimethyl 5-(4-cyanophenyl)pyrrolidine-2,3,4-tricarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,4R,5S)-trimethyl 5-(4-cyanophenyl)pyrrolidine-2,3,4-tricarboxylate

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Technology Process of (2R,3S,4R,5S)-trimethyl 5-(4-cyanophenyl)pyrrolidine-2,3,4-tricarboxylate

There total 1 articles about (2R,3S,4R,5S)-trimethyl 5-(4-cyanophenyl)pyrrolidine-2,3,4-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 126079-18-3
(4-cyanobenzylideneamino)acetic acid methyl ester

: 624-48-6
dimethyl cis-but-2-ene-1,4-dioate

: 1093167-95-3
(2R,3S,4R,5S)-trimethyl 5-(4-cyanophenyl)pyrrolidine-2,3,4-tricarboxylate

: (2S,3R,4S,5R)-trimethyl 5-(4-cyanophenyl)pyrrolidine-2,3,4-tricarboxylate

Guidance literature:: With (S)-(-)-α,α-bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol; triethylamine; iron(II) chloride; In acetonitrile; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2010.11.091