2-(acetylamino)-2-[(acetyloxy)methyl]-4-{4-[2-(1,1,1-trimethylsilyl)-1-ethynyl]phenyl}butyl acetate

Base Information

• Chemical Name: 2-(acetylamino)-2-[(acetyloxy)methyl]-4-{4-[2-(1,1,1-trimethylsilyl)-1-ethynyl]phenyl}butyl acetate
• CAS No.: 1070895-19-0
• Molecular Formula: C₂₂H₃₁NO₅Si
• Molecular Weight: 417.577

Synonyms:2-(acetylamino)-2-[(acetyloxy)methyl]-4-{4-[2-(1,1,1-trimethylsilyl)-1-ethynyl]phenyl}butyl acetate

Chemical Property of 2-(acetylamino)-2-[(acetyloxy)methyl]-4-{4-[2-(1,1,1-trimethylsilyl)-1-ethynyl]phenyl}butyl acetate

Chemical Property:

Purity/Quality:

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Technology Process of 2-(acetylamino)-2-[(acetyloxy)methyl]-4-{4-[2-(1,1,1-trimethylsilyl)-1-ethynyl]phenyl}butyl acetate

There total 1 articles about 2-(acetylamino)-2-[(acetyloxy)methyl]-4-{4-[2-(1,1,1-trimethylsilyl)-1-ethynyl]phenyl}butyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-(acetylamino)-2-[(acetyloxy)methyl]-4-{4-[(trifluoromethanesulfonyl)oxy]phenyl}butyl acetate (1070895-18-9) + trimethylsilylacetylene (1066-54-2) → 2-(acetylamino)-2-[(acetyloxy)methyl]-4-{4-[2-(1,1,1-trimethylsilyl)-1-ethynyl]phenyl}butyl acetate (1070895-19-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In acetonitrile; for 1.5h; Reflux;

DOI:10.1016/j.bmc.2008.07.003

Reference yield: 94.0%

2-(acetylamino)-2-[(acetyloxy)methyl]-4-{4-[2-(1,1,1-trimethylsilyl)-1-ethynyl]phenyl}butyl acetate (1070895-19-0) → C19H22BrNO5 (1070895-20-3)

Guidance literature:

With N-Bromosuccinimide; silver nitrate; In acetone; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2008.07.003

Reference yield: 80.0%

2-(acetylamino)-2-[(acetyloxy)methyl]-4-{4-[2-(1,1,1-trimethylsilyl)-1-ethynyl]phenyl}butyl acetate (1070895-19-0) → 2-amino-2-[4-(1-ethynyl)phenethyl]-1,3-propanediol (1070895-10-1)

Guidance literature:

With lithium hydroxide; In methanol; water; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2008.07.003

upstream raw materials:

2-(acetylamino)-2-[(acetyloxy)methyl]-4-{4-[(trifluoromethanesulfonyl)oxy]phenyl}butyl acetate

trimethylsilylacetylene

Downstream raw materials:

C₁₉H₂₂BrNO₅

2-amino-2-[4-(1-ethynyl)phenethyl]-1,3-propanediol

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