N-Benzyl-N'-[5-(2-trifluoromethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-guanidine

Base Information

Chemical Name:N-Benzyl-N'-[5-(2-trifluoromethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-guanidine
CAS No.:107114-86-3
Molecular Formula:C₁₇H₁₄F₃N₅S
Molecular Weight:377.393
Hs Code.:

Synonyms:N-Benzyl-N'-[5-(2-trifluoromethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-guanidine

Suppliers and Price of N-Benzyl-N'-[5-(2-trifluoromethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-guanidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Benzyl-N'-[5-(2-trifluoromethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-guanidine

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Technology Process of N-Benzyl-N'-[5-(2-trifluoromethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-guanidine

There total 2 articles about N-Benzyl-N'-[5-(2-trifluoromethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 107114-92-1
2-cyanamido-5-<2-(trifluorometyl)phenyl>-1,3,4-thiadiazole

: 100-46-9
benzylamine

: 107114-86-3
N-Benzyl-N'-[5-(2-trifluoromethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-guanidine

Guidance literature:: In butan-1-ol; at 110 - 120 ℃; for 16h;
DOI:10.1021/jm00388a038

Reference yield:

: 107115-00-4
2-chloro-5-[2-(trifluoromethyl)phenyl]-1,3,4-thiadiazole

: 107114-86-3
N-Benzyl-N'-[5-(2-trifluoromethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-guanidine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / dimethylformamide / 16 h / Ambient temperature

2: 25 percent / butan-1-ol / 16 h / 110 - 120 °C

In N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/jm00388a038