(R)-2-Phenyl-2-((S)-2,2,2-trifluoro-1-phenyl-1-p-tolyl-ethylamino)-ethanol

Base Information

Chemical Name:(R)-2-Phenyl-2-((S)-2,2,2-trifluoro-1-phenyl-1-p-tolyl-ethylamino)-ethanol
CAS No.:203630-95-9
Molecular Formula:C₂₃H₂₂F₃NO
Molecular Weight:385.429
Hs Code.:

Synonyms:(R)-2-Phenyl-2-((S)-2,2,2-trifluoro-1-phenyl-1-p-tolyl-ethylamino)-ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-Phenyl-2-((S)-2,2,2-trifluoro-1-phenyl-1-p-tolyl-ethylamino)-ethanol

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Technology Process of (R)-2-Phenyl-2-((S)-2,2,2-trifluoro-1-phenyl-1-p-tolyl-ethylamino)-ethanol

There total 3 articles about (R)-2-Phenyl-2-((S)-2,2,2-trifluoro-1-phenyl-1-p-tolyl-ethylamino)-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 2417-95-0
p-tolyllithium

: 203258-87-1
(2S,4R)-2,4-Diphenyl-2-trifluoromethyl-oxazolidine

: 203630-95-9
(R)-2-Phenyl-2-((S)-2,2,2-trifluoro-1-phenyl-1-p-tolyl-ethylamino)-ethanol

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 15h;
DOI:10.1016/S0040-4039(97)10840-1

Reference yield:

: 434-45-7
2,2,2-Trifluoroacetophenone

: 203630-95-9
(R)-2-Phenyl-2-((S)-2,2,2-trifluoro-1-phenyl-1-p-tolyl-ethylamino)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / PPTS / benzene / 50 h / Heating

2: tetrahydrofuran / 15 h / -78 °C

With pyridinium p-toluenesulfonate; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(97)10840-1

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 203630-95-9
(R)-2-Phenyl-2-((S)-2,2,2-trifluoro-1-phenyl-1-p-tolyl-ethylamino)-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / PPTS / benzene / 50 h / Heating

2: tetrahydrofuran / 15 h / -78 °C

With pyridinium p-toluenesulfonate; In tetrahydrofuran; benzene;
DOI:10.1016/S0040-4039(97)10840-1