Technology Process of 6-(benzyl(ethyl)amino)-2-methylisoindolin-1-one
There total 3 articles about 6-(benzyl(ethyl)amino)-2-methylisoindolin-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2-(2'-di-tert-butylphosphine)biphenylpalladium(II) acetate; sodium t-butanolate;
In
toluene; tert-butyl alcohol;
at 140 ℃;
for 0.25h;
Inert atmosphere;
Microwave irradiation;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: bromine; iron / 12 h / 20 °C
2: thionyl chloride / 3 h / 65 °C
3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 4 h / 75 °C
4: ammonium hydroxide / tetrahydrofuran; methanol / 4 h / 50 °C
5: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C
6: 2-(2'-di-tert-butylphosphine)biphenylpalladium(II) acetate; sodium t-butanolate / toluene; tert-butyl alcohol / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube
With
ammonium hydroxide; N-Bromosuccinimide; thionyl chloride; 2-(2'-di-tert-butylphosphine)biphenylpalladium(II) acetate; 2,2'-azobis(isobutyronitrile); bromine; iron; sodium hydride; sodium t-butanolate;
In
tetrahydrofuran; methanol; tetrachloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
6: Buchwald-Hartwig amination;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C
2: 2-(2'-di-tert-butylphosphine)biphenylpalladium(II) acetate; sodium t-butanolate / toluene; tert-butyl alcohol / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation; Sealed tube
With
2-(2'-di-tert-butylphosphine)biphenylpalladium(II) acetate; sodium hydride; sodium t-butanolate;
In
N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
2: Buchwald-Hartwig amination;
