2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Base Information

Chemical Name:2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline
CAS No.:1374107-71-7
Molecular Formula:C₃₀H₃₃N₃O₆S
Molecular Weight:563.675
Hs Code.:

Synonyms:2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Suppliers and Price of 2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

There total 8 articles about 2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 1374109-53-1
C₂₅H₂₅N₃O₅S

: 1374107-71-7
2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Guidance literature:: With toluene-4-sulfonic acid; In chloroform; at 20 ℃; for 0.333333h;

Reference yield:

: 19315-93-6
quinoline-2,6-diol

: 1374107-71-7
2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / 16 h / 20 °C / Cooling with ice

2.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 2.5 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / Cooling with ice; Inert atmosphere

4.2: 0.58 h / 20 °C / Cooling with ice

5.1: trifluoroacetic acid / chloroform / 1 h / 20 °C / Cooling with ice

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 17 h / 20 °C / Cooling with ice

7.1: trifluoroacetic acid / chloroform / 16 h / 20 °C / Cooling with ice

8.1: toluene-4-sulfonic acid / chloroform / 0.33 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; N,N-dimethyl-formamide; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 577967-89-6
6-hydroxy-2-chloroquinoline

: 1374107-71-7
2-(2-methylaminopyrid-5-yl)-6-[[2-(tetrahydro-2H-pyran-2-yloxy)-3-tosyloxy]propoxy]quinoline

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyridinium p-toluenesulfonate / tetrahydrofuran / 2.5 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 16 h / 80 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / Cooling with ice; Inert atmosphere

3.2: 0.58 h / 20 °C / Cooling with ice

4.1: trifluoroacetic acid / chloroform / 1 h / 20 °C / Cooling with ice

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 17 h / 20 °C / Cooling with ice

6.1: trifluoroacetic acid / chloroform / 16 h / 20 °C / Cooling with ice

7.1: toluene-4-sulfonic acid / chloroform / 0.33 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;