Technology Process of (6S,8αR)-6-benzenesulfinylmethyl-8α-isopropyl-dihydro-oxazolo[4,3-c]-[1,4]oxazine-3,5,8-trione
There total 14 articles about (6S,8αR)-6-benzenesulfinylmethyl-8α-isopropyl-dihydro-oxazolo[4,3-c]-[1,4]oxazine-3,5,8-trione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
tetrahydrofuran;
at -78 - 20 ℃;
DOI:10.1021/ol0609208
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: CH2Cl2 / 168 h / 4 °C
2.1: KHMDS / tetrahydrofuran; toluene / 0.5 h / -78 °C
2.2: tetrahydrofuran; toluene / -78 - -30 °C
3.1: 12.6 g / DDQ / H2O; CH2Cl2 / 23 °C
4.1: NaH / tetrahydrofuran / 0 - 20 °C
5.1: 3.4 g / LiHMDS / tetrahydrofuran / -78 - 20 °C
6.1: TiCl4; anisole / CH2Cl2 / 2 h / 20 °C
7.1: HF / acetonitrile / 2 h / 20 °C
8.1: 1.3 g / triethylamine; pivaloyl chloride / tetrahydrofuran / 23 °C
9.1: 80 percent / mCPBA / tetrahydrofuran / -78 - 20 °C
With
hydrogen fluoride; pivaloyl chloride; titanium tetrachloride; potassium hexamethylsilazane; sodium hydride; methoxybenzene; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/ol0609208
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: KHMDS / tetrahydrofuran; toluene / 0.5 h / -78 °C
1.2: tetrahydrofuran; toluene / -78 - -30 °C
2.1: 12.6 g / DDQ / H2O; CH2Cl2 / 23 °C
3.1: NaH / tetrahydrofuran / 0 - 20 °C
4.1: 3.4 g / LiHMDS / tetrahydrofuran / -78 - 20 °C
5.1: TiCl4; anisole / CH2Cl2 / 2 h / 20 °C
6.1: HF / acetonitrile / 2 h / 20 °C
7.1: 1.3 g / triethylamine; pivaloyl chloride / tetrahydrofuran / 23 °C
8.1: 80 percent / mCPBA / tetrahydrofuran / -78 - 20 °C
With
hydrogen fluoride; pivaloyl chloride; titanium tetrachloride; potassium hexamethylsilazane; sodium hydride; methoxybenzene; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/ol0609208
![(6S,8αR)-8α-isopropyl-6-phenylsulfanylmethyl-dihydro-oxazolo[4,3-c]-[1,4]oxazine-3,5,8-trione](/Databaselist/images/loading.webp)
