(S)-2-((S)-2-(3-(3,4-dichlorobenzyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid

Base Information

• Chemical Name: (S)-2-((S)-2-(3-(3,4-dichlorobenzyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid
• CAS No.: 923972-28-5
• Molecular Formula: C₂₁H₂₄Cl₂N₄O₄
• Molecular Weight: 467.352
• Mol file: 923972-28-5.mol

Synonyms:(S)-2-((S)-2-(3-(3,4-dichlorobenzyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid

Chemical Property of (S)-2-((S)-2-(3-(3,4-dichlorobenzyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-(3-(3,4-dichlorobenzyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid

There total 1 articles about (S)-2-((S)-2-(3-(3,4-dichlorobenzyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dichloro-4-isocyanatomethylbenzene (19752-09-1) + (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid (175453-07-3,142994-45-4) → (S)-2-((S)-2-(3-(3,4-dichlorobenzyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid (923972-28-5)

Guidance literature:

Multistep reaction;

DOI:10.1021/jm060978s

Reference yield:

(S)-2-((S)-2-(3-(3,4-dichlorobenzyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid (923972-28-5) + (S)-1-(4-amino-5-oxo-5-(thiazol-2-yl)pentyl)-3-(4-methoxy-2,3,6-trimethylphenylsulfonyl)guanidine trifluoroacetic acid salt → C40H49Cl2N9O7S2 (923972-19-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/jm060978s

Reference yield:

(S)-2-((S)-2-(3-(3,4-dichlorobenzyl)ureido)-3-(pyridin-3-yl)propanamido)-3-methylbutanoic acid (923972-28-5) → 1-(3,4-dichlorobenzyl)-3-((S)-1-((S)-1-((S)-5-guanidino-1-oxo-1-(thiazol-2-yl)pentan-2-ylamino)-3-methyl-1-oxobutan-2-ylamino)-1-oxo-3-(pyridin-3-yl)propan-2-yl)urea trifluoroacetic acid salt

Guidance literature:

Multi-step reaction with 2 steps

1: 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / tetrahydrofuran / 3 h / 20 °C

2: 8 mg / thioanisole; H₂O / 3 h / 20 °C

With methyl-phenyl-thioether; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1021/jm060978s

upstream raw materials:

1,2-dichloro-4-isocyanatomethylbenzene

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-3-yl)propanoic acid

Downstream raw materials:

C₄₀H₄₉Cl₂N₉O₇S₂