([4-(4-fluoro-phenoxy)-benzenesulphonyl]-hydroxycarbamoylmethyl-amino) acetic acid

Base Information

Chemical Name:([4-(4-fluoro-phenoxy)-benzenesulphonyl]-hydroxycarbamoylmethyl-amino) acetic acid
CAS No.:1196056-34-4
Molecular Formula:C₁₆H₁₅FN₂O₇S
Molecular Weight:398.369
Hs Code.:

Synonyms:([4-(4-fluoro-phenoxy)-benzenesulphonyl]-hydroxycarbamoylmethyl-amino) acetic acid

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Chemical Property of ([4-(4-fluoro-phenoxy)-benzenesulphonyl]-hydroxycarbamoylmethyl-amino) acetic acid

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Technology Process of ([4-(4-fluoro-phenoxy)-benzenesulphonyl]-hydroxycarbamoylmethyl-amino) acetic acid

There total 3 articles about ([4-(4-fluoro-phenoxy)-benzenesulphonyl]-hydroxycarbamoylmethyl-amino) acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1196056-30-0
{[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-carboxymethyl-amino}-acetic acid

: 1196056-34-4
([4-(4-fluoro-phenoxy)-benzenesulphonyl]-hydroxycarbamoylmethyl-amino) acetic acid

Guidance literature:: {[4-(4-Fluoro-phenoxy)-benzenesulphonyl]-carboxymethyl-amino}-acetic acid; With 4-methyl-morpholine; In tetrahydrofuran; at 0 ℃; for 0.666667h;

With hydroxylamine hydrochloride; potassium hydroxide; In tetrahydrofuran; methanol; at 0 ℃; for 2.5h;

Reference yield:

: 192329-91-2
4-(4-fluorophenoxy)benzenesulfonyl chloride

: 1196056-34-4
([4-(4-fluoro-phenoxy)-benzenesulphonyl]-hydroxycarbamoylmethyl-amino) acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: formic acid / 20 °C / Inert atmosphere

3: chloroformic acid ethyl ester; 4-methyl-morpholine; hydroxylamine hydrochloride / 2 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; formic acid; hydroxylamine hydrochloride; chloroformic acid ethyl ester; triethylamine; In dichloromethane;
DOI:10.1371/journal.pone.0187767

Reference yield:

: 1196056-28-6
{[4-(4-fluoro-phenoxy)-benzenesulphonyl]-tert-butoxycarbonylmethyl-amino}-acetic acid tert-butyl ester

: 1196056-34-4
([4-(4-fluoro-phenoxy)-benzenesulphonyl]-hydroxycarbamoylmethyl-amino) acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid / 20 °C / Inert atmosphere

2: chloroformic acid ethyl ester; 4-methyl-morpholine; hydroxylamine hydrochloride / 2 h / 0 °C / Inert atmosphere

With 4-methyl-morpholine; formic acid; hydroxylamine hydrochloride; chloroformic acid ethyl ester;
DOI:10.1371/journal.pone.0187767