(2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-4-pentynamide hydrochloride

Base Information

Chemical Name:(2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-4-pentynamide hydrochloride
CAS No.:1269408-32-3
Molecular Formula:C₁₆H₁₇N₅O₃*ClH
Molecular Weight:363.804
Hs Code.:

Synonyms:(2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-4-pentynamide hydrochloride

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Chemical Property of (2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-4-pentynamide hydrochloride

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Technology Process of (2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-4-pentynamide hydrochloride

There total 4 articles about (2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-4-pentynamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1269407-01-3
1,1-dimethylethyl [(1S)-1-({[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]amino}carbonyl)-3-butyn-1-yl]carbamate

: 1269408-32-3
(2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-4-pentynamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 50 ℃; for 1h;

Reference yield:

: 17417-09-3
2-fluoro-5-nitrobenzonitrile

: 1269408-32-3
(2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-4-pentynamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 1 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: triethylamine; HATU / dichloromethane / 2 h / 20 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 50 °C

With hydrogenchloride; potassium carbonate; triethylamine; HATU; In 1,4-dioxane; dichloromethane; acetonitrile;

Reference yield:

: 1269406-69-0
1,1-dimethylethyl [(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]carbamate

: 1269408-32-3
(2S)-2-amino-N-[(3S)-1-(2-cyano-4-nitrophenyl)-3-pyrrolidinyl]-4-pentynamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

2: triethylamine; HATU / dichloromethane / 2 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 1 h / 50 °C

With hydrogenchloride; triethylamine; HATU; In 1,4-dioxane; dichloromethane;